A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Placental Histology in Puerperant Women with Chronic Pyelonephritis, in Relation to Whether or Not Hyperbaric Oxygen Therapy Was Given during Pregnancy

For citation: Orazmuradov А. А., Savenkova I. V., Minaeva A. V., Khubetsova M. T., Paendi O. L., Lukaev A. A. Placental Histology in Puerperant Women with Chronic Pyelonephritis, in Relation to Whether or Not Hyperbaric Oxygen Therapy Was Given during Pregnancy. Doctor.Ru. 2017; 9(138): 48–51.

Study Design: This was a prospective study.

Materials and Methods: Ninety-seven pregnant women at five to 40 weeks’ gestation were examined and stratified into two statistically comparable groups. The main group consisted of 53 women with chronic pyelonephritis, and the control group was made up of 44 women without extragenital diseases. The main group was then divided into two subgroups by type of treatment: conventional treatment (n = 26) or treatment including HBOT (n = 27). HBOT was given in weeks six to nine, 16 to 18, and 24 to 28 of gestation, using the BLKS-307-Khrunichev, an individual therapeutic hyper/hypobaric oxygen chamber. The placentas were examined using a standardized protocol, including gross examination, sampling, and histology.

Statistical analysis of the study data was done using Statistica 8.0 software. Differences between the groups were assessed by one-way analysis of variance with Tukey’s post-hoc test. Parameter differences of p < 0.05 were considered statistically significant.

Study Results: In 42.3% of the placental samples obtained from women with chronic pyelonephritis who had not received HBOT during pregnancy, examination revealed, among chorionic villi of varying maturity, foci of leukocyte infiltration and necrobiosis (placentitis), as well as placental infarctions, arteritis, and phlebitis.

Among women with chronic pyelonephritis who had received HBOT during pregnancy, foci of leukocyte infiltration and necrobiosis (placentitis), accompanied by placental infarctions, arteritis, and phlebitis, were found in 18.5% of the samples, which was less frequent by a factor of 2.3 (p < 0.05) than in the women who had received conventional treatment alone.

Conclusion: HBOT is a promising method for improving placental morphology and functionality in pregnant women with chronic pyelonephritis. The optimal timing for HBOT in the study cohort is as follows: 1) weeks six to eight, when the cytotrophoblast grows through the endometrium (first wave of cytotrophoblast invasion), and 2) weeks 16 to 18, when the cytotrophoblast invades the myometrium (second wave of cytotrophoblast invasion).

А. А. Orazmuradov — Peoples’ Friendship University of Russia, Moscow. E-mail: leily_oraz@mail.ru

I. V. Savenkova — Peoples’ Friendship University of Russia, Moscow. E-mail: leily_oraz@mail.ru

A. V. Minaeva — Peoples’ Friendship University of Russia, Moscow. E-mail: leily_oraz@mail.ru

M. T. Khubetsova — Peoples’ Friendship University of Russia, Moscow. N. E. Bauman City Clinical Hospital No.29, Moscow City Department of Health. E-mail: leily_oraz@mail.ru

O. L. Paendi — City Outpatient Clinic No. 170, Moscow City Department of Health. E-mail: paendi.olga@yandex.ru

A. A. Lukaev — Mytishchi City Clinical Hospital Perinatal Center. E-mail: aleksei_lukaev@mail.ru


Доктор.ру
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