Cesarean Section: Oxidative-Stress Parameters in Perioperative Period

Study Objective: To assess systemic pro-oxidative and anti-oxidative activity in the perioperative period in pregnant women who had an elective cesarean section under regional anesthesia (combined spinal and epidural anesthesia) or general anesthesia.

Study Design: This was an observational, analytical, case-control study.

Materials and Methods: We observed 62 pregnant women who gave birth by cesarean section. The following oxidative-stress parameters were measured: levels of superoxide dismutase, glutathione peroxidase, reduced glutathione, and thiobarbituric acid reactive substances (TBARS), and total antioxidative activity.

Study Results: The study showed that regional and general anesthesia provided for cesarean section have different impact on oxidative stress in the intraoperative and immediate postoperative periods.

Conclusion: Identifying critical phases in the perioperative period helps timely detect negative changes and, through this, predict possible complications.

V. A. Burlev — V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow. E-mail: vbourlev@mail.ru

A. V. Burlev — Maternity Hospital No. 11, Moscow Department of Healthcare. E-mail: redaktor@rusmg.ru

N. A. Ilyiasova — V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow. E-mail: redaktor@rusmg.ru

E. M. Shifman — Peoples’ Friendship University of Russia, Moscow. E-mail: redaktor@rusmg.ru

  1. Бурлев А. В., Бурлев В. А., Ильясова Н. А., Сокологорский С. В. и др. Ангиогенные факторы роста в спинномозговой жидкости беременных при комбинированной спинально-эпидуральной анестезии при плановой операции кесарева сечения // Анестезиология и реаниматология. 2012. № 6. С. 39–44.
  2. Бурлев А. В., Бурлев В. А., Ильясова Н. А., Шифман Е. М. и др. Таргетные эффекты ангиогенно-воспалительного стресса у пациенток в периоперационном периоде при регионарной и общей анестезии плановой операции кесарева сечения // Акушерство и гинекология. 2012. № 8–2. С. 33–41.
  3. Бурлев В. А. Свободнорадикальное окисление в системе мать-плацента-плод при акушерской патологии: Дис. … докт. мед. наук. М., 1992. С. 50.
  4. Сокологорский С. В., Бурлев В. А., Ковалев В. Ф., Лапшина И. И. Компьютерный мониторинг, отражающий взаимосвязь показателей доставки кислорода и перекисного окисления липидов // Анестезиология и реаниматология. 2003. № 3. С. 37–40.
  5. Adler V., Yin Z., Tew K. D., Ronai Z. Role of redox potential and reactive oxygen species in stress signaling // Oncogene. 1999. Vol. 18. N 45. Р. 6104–6111.
  6. Cuzzocrea S., Riley D. P., Caputi A. P., Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury // Pharmacol. Rev. 2001. Vol. 53. N 1. Р. 135–159.
  7. Ehlers R. A., Hernandez A., Bloemendal L. S., Ethridge R. T. et al. Mitochondrial DNA damage and altered membrane potential in pancreatic acinar cells induced by reactive oxygen species // Surgery. 1999. Vol. 126. N 2. Р. 148–155.
  8. Fassoulaki A., Petropoulos G., Staikou C., Siafaka I. et al. General versus neuraxial anaesthesia for caesarean section: impact on the duration of hospital stay // Obstet. Gynaecol. 2009. Vol. 29. N 1. Р. 25–30.
  9. Fassoulaki A., Staikou C., Melemeni A., Kottis G. et al. Anaesthesia preference, neuraxial vs general, and outcome after caesarean section // Obstet. Gynaecol. 2010. Vol. 30. N 8. Р. 818–821.
  10. Fogel I., Pinchuk I., Kupferminc M. J., Lichtenberg D. et al. Oxidative stress in the fetal circulation does not depend on mode of delivery // Am. J. Obstet. Gynecol. 2005. Vol. 193. N 1. Р. 241–246.
  11. Hatwalne M. S. Free radical scavengers in anaesthesiology and critical careIndian // Ind. J. Anesth. 2012. Vol. 56. N 3. Р. 227–233.
  12. Hracsko Z., Safar Z., Orvos H., Novak Z. et al. Evaluation of oxidative stress markers after vaginal delivery or Caesarean section // In Vivo. 2007. Vol. 21. N 4. Р. 703–706.
  13. Lawler J. M., Powers S. K. Oxidative stress, antioxidant status, and the contracting diaphragm // Can. J. Appl. Physiol. 1998. Vol. 23. N 1. Р. 23–55.
  14. Littleford J. Effects on the fetus and newborn of maternal analgesia and anesthesia: a review // Can. J. Anesth. 2004. Vol. 51. N 6. Р. 586–609.
  15. Malik E., Buchweitz O., Müller-Steinhardt M., Kressin P. et al. Prospective evaluation of the systemic immune response following abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy // Surg. Endosc. 2001. Vol. 15. N 5. Р. 463–466.
  16. Mutlu B., Aksoy N., Cakir H., Celik H. et al. The effects of the mode of delivery on oxidative-antioxidative balance // J. Matern. Fetal Neonatal Med. 2011. Vol. 24. N 11. Р. 1367–1370.
  17. Ortolani O., Conti A., De Gaudio A. R., Masoni M. et al. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome // Shock. 2000. Vol. 13. N 1. Р. 14–18.
  18. Raijmakers M. T., Roes E. M., Steegers E. A., van der Wildt B. et al. Umbilical glutathione levels are higher after vaginal birth than after cesarean section // J. Perinat. Med. 2003. Vol. 31. N 6. Р. 520–522.
  19. Schoonover L. L. Oxidative stress and the role of antioxidants in cardiovascular risk reduction // Prog. Cardiovasc. Nurs. 2001. Vol. 16. N 1. Р. 30–32.
  20. Wang C. H., Wu S. B., Wu Y. T., Wei Y. H. Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging // Exp. Biol. Med. (Maywood). 2013. Vol. 238. N 5. P. 450–460.

Похожие статьи


1 October 10:52
A New Issue of Doctor.Ru Internal Medicine, Vol. 21, No. 6 (2022), Published

Find original articles and reviews covering various aspects of сardiology, gastroenterology, internal medicine and the interview with Professor Alexey Nikolaevich Kalyagin

7 July 17:16
A New Issue of Doctor.Ru Neurology Psychiatry, Vol. 21, No. 4 (2022), Published

Find original articles and reviews covering various aspects of neurology, psychiatry and the interview with Professor Alexander Vitalievich Amelin

12 May 11:25
A New Issue of Doctor.Ru Pediatrics, Vol. 21 No. 3 (2022), Published

See the original papers, reviews and clinical cases in headings Pulmonology, Rheumatology, Endocrinology, Neurology, Cross-disciplinary approach and Interview with with an Honoured Scientist of the Sakha (Yakutia) Republic Professor Maria Vasilievna Khandy

4 May 10:02
A New Issue of Doctor.Ru Internal Medicine, Vol. 21, No. 2 (2022), Published

Find original articles and reviews covering various aspects of gastroenterology, internal medicine, rheumatology, endocrinology, special section of postgraduate training and the interview with Professor Dmitry Alexeevich Sychev

18 March 00:00
A New Issue of Doctor.Ru Gynecology, Vol. 21 No. 1 (2022), Published

Find original articles and reviews covering various aspects of obstetrics, perinatology and gynecology, and the interview with Feldberg Dov, MD

All news