Optimal Treatment of Bacterial Vaginosis before Delivery

Bibliography link: Selikhova M.S., Ababekyan N.V. Optimal Treatment of Bacterial Vaginosis before Delivery. Doctor.Ru. 2020; 19(6): 36–39. (in Russian) DOI: 10.31550/1727-2378-2020-19-6-36-39
23 July 15:24

Study Objective: To assess the efficacy and safety of Depanthol vaginal suppositories in the treatment of bacterial vaginosis before delivery and evaluate the frequency and types of maternal trauma during delivery in these women.

Study Design: This was an observational retrospective and prospective study.

Materials and Methods: Eighty-seven pregnant women with a verified diagnosis of bacterial vaginosis were examined at weeks 34-37 of gestation. All the women were admitted to hospital and underwent an examination in accordance with current standards, including microscopy of the vaginal secretions. All the participants were given one Depanthol vaginal suppository twice daily for 10 days.

Study Results: After treatment, genital discharge remained only in five women. None of the patients reported vaginal malodor, itching, burning, or vaginal discomfort. Repeat pH measurement showed that only two women had pH ≥ 4.5. Follow-up microscopy of vaginal discharge, performed after treatment, again showed signs of bacterial vaginosis (clue cells) in six (7.1%) women. None of the patients experienced adverse events.

Analysis of the labor and delivery histories of the study participants demonstrated that the number of cases of cervical rupture and episiotomy did not significantly decrease compared to the general population. Of note, women who received Depanthol prior to delivery did not have severe trauma to soft tissue in the birth canal, such as grade 3 cervical rupture, vaginal hematoma, or grade 3 perineal laceration.

Conclusion: Dexpanthenol, a component of Depanthol that contributes to normalizing vaginal microbiota and restoring the mucosal protective barrier, as well as to reducing the frequency of trauma to soft tissue in the birth canal, gives Depanthol advantages over other medications used to treat bacterial vaginosis during pregnancy. Depanthol is the medication of choice for treating bacterial vaginosis before delivery, and may be recommended for wide use in obstetrical/gynecological practice.

Contributions: Dr. M.S. Selikhova was responsible for designing the study, reviewing relevant publications, and writing and approving the final manuscript. Dr. N.V. Ababekyan collected and analyzed data. 

Conflict of interest: The authors declare that they do not have any conflict of interests.

M.S. Selikhova (Corresponding author) — Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Pavshikh Bortsov Square, Volgograd, Russian Federation 400131. E-mail:

N.V. Ababekyan — Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Pavshikh Bortsov Square, Volgograd, Russian Federation 400131. Clinical Hospital No. 5 (a State Healthcare Institution); 2 Pelshe St., Volgograd, Russian Federation 400009. E-mail:


Received: 08.05.2020
Accepted: 14.05.2020

23 July 15:24
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