ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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The Impact of Impaired Serum and Amniotic Fluid Cytokine Profiles on the Risk of Preterm Delivery

DOI:10.31550/1727-2378-2019-159-4-19-22
Bibliography link: Krukier I.I., Levkovich M.A., Mikhelson A.F., Lebedenko E.Yu., Erdzhanyan L.L., Mikhelson A.A., Smolyaninov G.V., Popova N.N. The Impact of Impaired Serum and Amniotic Fluid Cytokine Profiles on the Risk of Preterm Delivery. Doctor.Ru. 2019; 4(159): 19–22. DOI: 10.31550/1727-2378-2019-159-4-19-22
30 April 08:00

Study Objective: To evaluate cytokine production in the amniotic fluid and maternal serum in normal and complicated pregnancies and their impact on the risk of preterm delivery.

Study Design: This was a prospective, open-label, comparative study.

Materials and Methods: One hundred and eighteen women were examined in the study, including 70 women with normal pregnancies and 48 women with placental insufficiency, who had preterm deliveries at 35-37 weeks. The following cytokines were measured in the maternal serum and amniotic fluid by immunofluorescence analysis: tumor necrosis factor α (TNF-α) and interleukins (IL) IL-1 β, IL-6, IL-12, and IL-10.

Study Results: In the women with preterm deliveries amniotic levels of TNF-α, IL-12, and IL-6 were 3, 2.5, and 2.3 times higher, respectively, and those of IL-10 were lower by a factor of 2.5, than in the women with normal pregnancies. Similar but not as marked trends were observed in serum cytokine production in the women with preterm deliveries: levels of IL-12, TNF-α, IL-1 β, and IL-6 were 2, 1.7, 1.6, and 1.5 times higher, respectively. Serum levels of IL-10 were lower by a factor 2.5.

Conclusion: The study data suggest that these cytokines play a certain role in the development of cell disintegration. Changes in their levels in the amniotic fluid is a key factor, serving as an indirect indicator that these changes are of fetal origin and that the fetus influences the initiation of labor.

The authors declare that they do not have any conflict of interests.

I.I. Krukier — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: biochem@rniiap.ru

M.A. Levkovich — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: xlma@mail.ru

A.F. Mikhelson — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: michelson.a.f.@mail.ru

E.Yu. Lebedenko — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: lebedenko@mail.ru

L.L. Erdzhanyan — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: docerdzhanian@gmail.com

A.A. Mikhelson — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: Artur.Mikhelson@gmail.com

G.V. Smolyaninov — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: solomea2017@yandex.ru

N.N. Popova — Rostov State Medical University, Russian Ministry of Health; 43 Mechnikov St., Rostov-on-Don, Russian Federation 344012. E-mail: solomea2017@yandex.ru

Доктор.ру
30 April 08:00
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