ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Predicting Pre-Eclampsia in the First Half of Pregnancy

Bibliography link: Ivanova O. Yu., Ponomareva N. A., Gazazyan M. G., Velikoretskaya O. A. Predicting Pre-Eclampsia in the First Half of Pregnancy. Doctor.Ru. 2017; 7(136): 33–37.
20 July 00:00

Study Objective: To identify objective prognostic criteria for pre-eclampsia (PE) in the first half of pregnancy.

Materials and Methods: Two hundred and nine patients who later gave birth to live, full-term babies after a singleton pregnancy underwent periodic comprehensive examinations during pregnancy. They were divided retrospectively into two groups, based on pregnancy and delivery outcomes. The control group consisted of 84 patients without complications during pregnancy, labor or delivery. The main group was composed of 125 pregnant women with moderate or severe PE. The following tests and investigations were performed on all participants: measurements of PAPP-A, β-HCG, and PAMG-1 levels, echocardiography of maternal central hemodynamics, and assessment of endothelium-dependent vasodilation.

Study Results: A combination of signs suggestive of incomplete trophoblast invasion, changes in central hemodynamics indicating maladaptation, and disturbed endothelial vasomotor function is a prognostic marker for PE.

Conclusion: If, by weeks 17-20 of gestation, minute volume (MV) increases in excess of 13-14%, peripheral vascular resistance (PVR) decreases by more than 10-11%, and endothelial function improves by at least 4%, this predicts that the pregnancy will proceed without complications (without PE). If the increase in MV is less than 10%, the decrease in PVR does not exceed 7%, and endothelial function worsens or only slightly (by less than 4%) improves by the end of the first half of pregnancy, this predicts that PE will develop.


O. Yu. Ivanova — Kursk State Medical University. E-mail: ivanovao1@mail.ru

N. A. Ponomareva — Kursk State Medical University. E-mail: ivanovao1@mail.ru

M. G. Gazazyan — Kursk State Medical University. E-mail: omal4@rambler.ru

O. A. Velikoretskaya — Lipetsk-Med — City Hospital No. 4. E-mail: v.olyamama@mail.ru

Доктор.ру
20 July 00:00
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