ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Persistence of the Eosinophilic Phenotype in Preschool Children with Mild Bronchial Asthma

DOI:10.31550/1727-2378-2019-160-5-47-51
Bibliography link: Fedorov I.A., Rybakova O.G. Persistence of the Eosinophilic Phenotype in Preschool Children with Mild Bronchial Asthma. Doctor.Ru. 2019; 5(160): 47–51. DOI: 10.31550/1727-2378-2019-160-5-47-51
13 May 17:49

Study Objective: To study the dynamic characteristics of the inflammatory phenotype and cytoimmunologic features of induced sputum (IS) in preschool children with mild persistent bronchial asthma (BA).

Study Design: prospective cohort study.

Materials and Methods: 53 children with mild persistent BA aged 1.5 to 5 years (BA group) were followed up for 2 years. The control group included 20 non-allergic children of the same age.

In the beginning and at the end of the study, subjects had their blood eosinophils, total blood IgE, cell composition of nasal discharges (ND) and IS, IS immunolofy assessed.

Study Results: The majority of children with BA demonstrated high ND eosinophils (≥ 5%) and IS eosinophils (≥ 2.5%) counts throughout the study. In the beginning and at the end of the study, 60% of children with BA had eosinophilic inflammatory phenotype of IS; prevalence of combined inflammatory phenotype of IS did not significantly change as well (р > 0.05). Pro-inflammatory IS factors in children with BA were statistically higher (р < 0.05) than in controls, both in the beginning of the study and during BA remission.

Conclusion: These changes evidence persistent inflammation in BA even during mild BA remission.

The authors declare that they do not have any conflict of interests.

I.A. Fedorov — Yuzhno-Uralsky State Medical University of the Ministry of Health of Russia; 10 Ryleev Str., Chelyabinsk, Russian Federation 454092. E-mail: ifedorov@mail.ru

O.G. Rybakova — Yuzhno-Uralsky State Medical University of the Ministry of Health of Russia; 10 Ryleev Str., Chelyabinsk, Russian Federation 454092. E-mail: gallo53@mail.ru

Доктор.ру
13 May 17:49
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