ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Role of Endothelial Growth Factor in Bronchial Asthma Control in Children

DOI:10.31550/1727-2378-2020-19-3-40-43
Bibliography link: Potapova N.L., Gaymolenko I.N., Tereshkov P.P. Role of Endothelial Growth Factor in Bronchial Asthma Control in Children. Doctor.Ru. 2020; 19(3): 40–43. (in Russian) DOI: 10.31550/1727-2378-2020-19-3-40-43
19 May 10:59

Study Objective: to study vascular endothelial growth factor (VEGF-A) levels in children with controlled and uncontrolled bronchial asthma (CBA and UBA).

Study Design: cross-sectional study.

Materials and Methods. 71 children with BA were examined (37 children with moderate and 34 children with severe BA); examination included history analysis, clinical examination, measurement of eosinophils in peripheral blood, total plasma IgE, spirometry. The mean age of patients was 9.0 ± 2.5 years old. VEGF-A concentration was measured in two independent samplings: with satisfactory BA control (n = 26) and UBA (n = 25).

Study Results. In moderate BA, VEGF-A concentration was 1.4-times higher in uncontrolled BA than in patients with satisfactory control. 1.8-times increase inVEGF-A concentration (р< 0.05) was noted in severe UBA as compared to CBA; it assumes VEGF-A synthesis initiation in children with long-term chronic respiratory inflammation and demonstrates its involvement in remodelling processes which are most prominent in uncontrolled BA. Interrelation analysis of VEGF-А and pulmonary ventilation indicators revealed significant moderate negative relation with forced expiratory volume during first second (rs = –0.34) and forced vital respiratory capacity (rs = –0.51) in severe UBA (р< 0.05).

Conclusion. Our results correlate with results of other studies where VEGF-A was treated as angiogenesis marker in bronchial remodelling. It allows assuming that it is a potential therapeutic target in development of antiangiogenics to control BA.

Contribution: Potapova, N.L. — patient selection, examination and management, thematic publications reviewing; Gaymolenko, I.N. — study design, review of critically important material, approval of the manuscript for publication; Tereshkov, P.P. — lab tests, data analysis and interpretation.

Conflict of interest: The authors declare that they do not have any conflict of interests.

N.L. Potapova (Corresponding author) — Chita State Medical Academy of the Ministry of Health of the Russian Federation; 39A Gorky Str., Chita, Russian Federation 672000. eLIBRARY.RU SPIN: 7460-4199. ORCID: http://orcid.org/0000-0002-9670-9211. E-mail: nataliapotap@yandex.ru

I.N. Gaymolenko — Chita State Medical Academy of the Ministry of Health of the Russian Federation; 39A Gorky Str., Chita, Russian Federation 672000. eLIBRARY.RU SPIN: 7875-0742. ORCID: http://orcid.org/0000-0002-8771-5230. E-mail: ingaim@mail.ru

P.P. Tereshkov — Chita State Medical Academy of the Ministry of Health of the Russian Federation; 39A Gorky Str., Chita, Russian Federation 672000. eLIBRARY.RU SPIN: 5228-8808. ORCID: http://orcid.org/0000-0002-8601-3499. E-mail: tpp69156@mail.ru

Доктор.ру

Table
Clinical profile of patients with controlled and uncontrolled bronchial asthma (CBA and UBA)

t7_1.jpg

* Difference from severe controlled bronchial asthma group under Mann-Whitney test is statistically significant (р < 0.05).

Received: 26.12.2019
Accepted: 20.01.2020

19 May 10:59
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