Study Objective: to study vascular endothelial growth factor (VEGF-A) levels in children with controlled and uncontrolled bronchial asthma (CBA and UBA).
Study Design: cross-sectional study.
Materials and Methods. 71 children with BA were examined (37 children with moderate and 34 children with severe BA); examination included history analysis, clinical examination, measurement of eosinophils in peripheral blood, total plasma IgE, spirometry. The mean age of patients was 9.0 ± 2.5 years old. VEGF-A concentration was measured in two independent samplings: with satisfactory BA control (n = 26) and UBA (n = 25).
Study Results. In moderate BA, VEGF-A concentration was 1.4-times higher in uncontrolled BA than in patients with satisfactory control. 1.8-times increase inVEGF-A concentration (р< 0.05) was noted in severe UBA as compared to CBA; it assumes VEGF-A synthesis initiation in children with long-term chronic respiratory inflammation and demonstrates its involvement in remodelling processes which are most prominent in uncontrolled BA. Interrelation analysis of VEGF-А and pulmonary ventilation indicators revealed significant moderate negative relation with forced expiratory volume during first second (rs = –0.34) and forced vital respiratory capacity (rs = –0.51) in severe UBA (р< 0.05).
Conclusion. Our results correlate with results of other studies where VEGF-A was treated as angiogenesis marker in bronchial remodelling. It allows assuming that it is a potential therapeutic target in development of antiangiogenics to control BA.
Contribution: Potapova, N.L. — patient selection, examination and management, thematic publications reviewing; Gaymolenko, I.N. — study design, review of critically important material, approval of the manuscript for publication; Tereshkov, P.P. — lab tests, data analysis and interpretation.
Conflict of interest: The authors declare that they do not have any conflict of interests.