Atypical Endometriosis of the Urinary Bladder: a Clinical Case

For citation: Bairamova N. N., Protasova A. E., Raskin G. A., Yarmolinskaya M. I., Bairamov Kh. N., Drozdov A. A. Atypical Endometriosis of the Urinary Bladder: a Clinical Case. Doctor.Ru. 2018. 6(150): 61–66.
10 september 2018

Objective of the Paper: To describe a clinical case of atypical endometriosis (AEM) of the urinary bladder.

Key Points: The paper describes a first-hand observation of a clinical case of AEM of the urinary bladder in a woman of reproductive age. The authors propose a panel of immunohistochemical markers that will improve the diagnosis of AEM, viewed as a morphological precancerous condition. They also discuss the latest data from the literature on the specific aspects of the pathogenesis, diagnosis, clinical course, treatment methods, and risk factors for malignant transformation of this rare condition.

Conclusion: Challenges in the differential diagnosis and histological verification of AEM of the urinary bladder make it necessary to evaluate the immunohistochemical expression of the BAF250a (ARID1a), β-catenin, PTEN, Ki-67, and p53 markers. Curative resection of areas of endometriosis combined with long-term adjuvant treatment with dienogest is the most effective therapeutic approach.

N. N. Bairamova — St. Petersburg State University. E-mail: nurana.bayramova@yandex.ru

A. E. Protasova — St. Petersburg State University. I. I. Mechnikov Northwestern State Medical University, St. Petersburg. V. A. Almazov National Medical Research Center, St. Petersburg. OOO AVA-PETER, St. Petersburg. E-mail: protasova1966@yandex.ru

G. A. Raskin — St. Petersburg State University. A. M. Granov Russian Scientific Center for Radiology and Surgical Technologies, St. Petersburg. E-mail: rasking@list.ru

M. I. Yarmolinskaya — I. I. Mechnikov Northwestern State Medical University, St. Petersburg. D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine, St. Petersburg. E-mail: m.yarmolinskaya@gmail.com

Kh. N. Bairamov — St. Petersburg State University. E-mail: khikmet.bairam@gmail.com

A. A. Drozdov — St. Petersburg State University. E-mail: a_a_drozdov@mail.ru

10 September 14:22
  1. Koninckx P. R., Ussia A., Adamyan L., Wattiez A., Donnez J. Deep endometriosis: definition, diagnosis, and treatment. Fertil. Steril. 2012; 98(3): 564–71. DOI: 10.1016/j.fertnstert.2012.07.1061
  2. Knabben L., Imboden S,. Fellmann B., Nirgianakis K., Kuhn A., Mueller M. D. Urinary tract endometriosis in patients with deep infiltrating endometriosis: prevalence, symptoms, management, and proposal for a new clinical classification. Fertil Steril 2015; 103(1): 147–52. DOI: 10.1016/j.fertnstert.2014.09.028
  3. Vigano` P., Somigliana E., Gentilini D., Benaglia L., Vercellini P. Back to the original question in endometriosis: implantation or metaplasia? J. Endometriosis. 2009; 1(1): 1–8. DOI: 10.1177/228402650900100102
  4. Donnez J., Spada F., Squifflet J., Nisolle M. Bladder endometriosis must be considered as bladder adenomyosis. Fertil. Steril. 2000; 74(6): 1175–81. DOI: 10.1016/S0015­0282(00)01584­3
  5. Leone Roberti Maggiore U., Ferrero S., Candiani M., Somigliana E., Viganò P., Vercellini P. Bladder endometriosis: a systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. Eur. Urol. 2017; 71(5): 790–807. DOI: 10.1016/j.eururo.2016.12.015.
  6. Guerriero S., Condous G., Van den Bosch T., Valentin L., Leone F. P. G., Van Schoubroeck D. et al. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound. Obstet. Gynecol. 2016; 48(3): 318–32. DOI: 10.1002/uog.15955
  7. Medeiros L. R., Rosa M. I., Silva B. R., Reis M. E., Simon C. S., Dondossola E. R. et al. Accuracy of magnetic resonance in deeply infiltrating endometriosis: a systematic review and meta­analysis. Arch. Gynecol. Obstet. 2015; 291(3): 611–21. DOI: 10.1007/s00404­014­3470­7
  8. Vercellini P., Carmignani L., Rubino T., Barbara G., Abbiati A., Fedele L. Surgery for deep endometriosis: a pathogenesis­oriented approach. Gynecol. Obstet. Investig. 2009; 68(2): 88–103. DOI: 10.1159/000219946
  9. Vercellini P., Buggio L., Berlanda N., Barbara G., Somigliana E., Bosari S. Estrogen­progestins and progestins for the management of endometriosis. Fertil. Steril. 2016; 106(7): 1552–71.e2. DOI: 10.1016/j.fertnstert.2016
  10. Leone Roberti Maggiore U., Ferrero S., Salvatore S. Urinary incontinence and bladder endometriosis: conservative management. Int. Urogynecol. J. 2015; 26(1): 159–62. DOI: 10.1007/s00192­014­2487­6
  11. Ferrero S., Alessandri F., Racca A., Leone Roberti Maggiore U.Treatment of pain associated with deep endometriosis: alternatives and evidence. Fertil. Steril. 2015; 104(4): 771–92. DOI: 10.1016/j.fertnstert.2015.08.031
  12. Del Pup L., Beretta M. As dienogest effectively suppresses endometriosis, could it also reduce endometriosis associated ovarian cancers? A further motivation for long­term medical treatment. World Cancer Res. J. 2015; 2(2): e526.
  13. Soriano D., Bouaziz J., Elizur S., Zolti M., Orvieto R., Seidman D. et al. Reproductive outcome is favorable after laparoscopic resection of bladder endometriosis. J. Minim. Invasive Gynecol. 2016; 23(5): 781–6. DOI: 10.1016/j.jmig.2016.03.015
  14. Давидов М. И., Пономарева Т. Б. Эндометриоз под маской рака мочевого пузыря (обзор литературы и описание трех собственных наблюдений). Онкоурология. 2016; 12 (1): 90–6. [Davidov M. I., Ponomareva T. B. Endometrioz pod maskoi raka mochevogo puzyrya (obzor literatury i opisanie trekh sobstvennykh nablyudenii). Onkourologiya. 2016; 12 (1): 90–6. (in Russian)] DOI: 10.17650/1726­9776­2016­12­1­90­96
  15. Wei J. J., William J., Bulun S. Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects. Int. J. Gynecol. Pathol. 2011; 30(6): 553–68. DOI: 10.1097/PGP.0b013e31821f4b85

Похожие статьи


1 October 10:52
A New Issue of Doctor.Ru Internal Medicine, Vol. 21, No. 6 (2022), Published

Find original articles and reviews covering various aspects of сardiology, gastroenterology, internal medicine and the interview with Professor Alexey Nikolaevich Kalyagin

7 July 17:16
A New Issue of Doctor.Ru Neurology Psychiatry, Vol. 21, No. 4 (2022), Published

Find original articles and reviews covering various aspects of neurology, psychiatry and the interview with Professor Alexander Vitalievich Amelin

12 May 11:25
A New Issue of Doctor.Ru Pediatrics, Vol. 21 No. 3 (2022), Published

See the original papers, reviews and clinical cases in headings Pulmonology, Rheumatology, Endocrinology, Neurology, Cross-disciplinary approach and Interview with with an Honoured Scientist of the Sakha (Yakutia) Republic Professor Maria Vasilievna Khandy

4 May 10:02
A New Issue of Doctor.Ru Internal Medicine, Vol. 21, No. 2 (2022), Published

Find original articles and reviews covering various aspects of gastroenterology, internal medicine, rheumatology, endocrinology, special section of postgraduate training and the interview with Professor Dmitry Alexeevich Sychev

18 March 00:00
A New Issue of Doctor.Ru Gynecology, Vol. 21 No. 1 (2022), Published

Find original articles and reviews covering various aspects of obstetrics, perinatology and gynecology, and the interview with Feldberg Dov, MD

All news