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Quality of Life and Depressive Symptoms in Women of Reproductive Age with Hyperprolactinemia

Bibliography link: Kuzmin M. Yu., Atalyan A. V., Suturina L. V. Quality of Life and Depressive Symptoms in Women of Reproductive Age with Hyperprolactinemia. Doctor.Ru. 2017; 13(142)—14(143): 52–56.
Quality of Life and Depressive Symptoms in Women of Reproductive Age with Hyperprolactinemia
19 December 00:00

Study Objective: To study quality of life and depressive symptoms in women of reproductive age with high and normal prolactin levels.

Study Design: This was a cross-sectional study.

Materials and Methods: Two hundred and seventy-two women of reproductive age, including 35 patients with hyperprolactinemia and 237 women without this condition, were examined during annual medical check-ups. In addition to a general physical examination, the Beck Depression Inventory and the Short Form-12 (SF-12) Health Survey Questionnaire were used in this study.

Study Results: The study analysis showed no significant difference between the women with hyperprolactinemia and those without it, in the intensity of depressive symptoms as assessed by total Beck Depression Inventory (BDI) score. Patients with hyperprolactinemia were, however, less satisfied with their quality of life (U = 2,405; p < 0.01) and more irritable (U = 2,192; p < 0.05). In addition, they more often reported weight loss (U = 2,379; p < 0.02). In the group of participants with hyperprolactinemia there was a negative correlation between the intensity of depressive symptoms and the quality of life total score (r = –0.55; p < 0.01), while in the group of women without hyperprolactinemia this correlation was weaker (r = –0.25; p < 0.01). This was most evident in analysis of the BDI cognitive-affective subscale and SF-12 total scores. In the group of patients with hyperprolactinemia, there was a strong negative correlation between these parameters (r = –0.57; p < 0.01); while in the group of women with normal prolactin levels this correlation was much weaker (r = –0.22; p < 0.02).

Multiple-factor logistic regression analysis showed that blood prolactin levels, together with smoking, influence depressive symptoms in women, but only somatic depressive symptoms.

Conclusion: This study showed a stronger correlation between cognitive-affective depressive symptoms and quality of life in women with hyperprolactinemia than in women without this condition. Blood prolactin levels and smoking influence the BDI somatic subscale score. The authors concluded that other potential confounders, which may influence the correlation between hyperprolactinemia and quality of life, should be further studied.

M. Yu. Kuzmin — Scientific Center for Family Health and Human Reproduction, Irkutsk. Irkutsk State University. E-mail: mirroy@mail.ru

A. V. Atalyan — Scientific Center for Family Health and Human Reproduction, Irkutsk. E-mail: atalyan@sbamsr.irk.ru

L. V. Suturina — Scientific Center for Family Health and Human Reproduction, Irkutsk. Irkutsk State Medical Academy of Postgraduate Education, a branch of the Russian Medical Academy of Continuing Professional Education. E-mail: l_suturina@sbamsr.irk.ru

Quality of Life and Depressive Symptoms in Women of Reproductive Age with Hyperprolactinemia
19 December 00:00
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