ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Managing Symptoms of Vaginal Atrophy during Treatment with Gonadotropin-Releasing Hormone Agonists

Bibliography link: T. A. Oboskalova, I. V. Lavrentieva, O. V. Prokhorova, A. V. Vorontsova. Managing Symptoms of Vaginal Atrophy during Treatment with Gonadotropin-Releasing Hormone Agonists. Doctor.Ru. 2016; 3(120): 30–33.
1 March 00:00

Study Objective: To improve the outcome of treatment with gonadotropin-releasing hormone agonists (GnRH-a) and to improve patients' quality of life by using local therapies to relieve symptoms of vaginal atrophy.

Study Design: This was an open-label, prospective, non-controlled study.

Materials and Methods: In 30 women who had symptoms of vaginal atrophy and used GnRH-a, complaints were assessed, using a visual analogue scale; a vaginal health index (VHI) score was calculated; vaginal pH was measured; and the number of Lactobacillus casei var. Rhamnosus Döderlein was determined before, during, and after treatment with (a medication containing 0.2 mg of estriol, 2.0 mg of progesterone, and 341 mg of L. casei var. Rhamnosus Döderlein (Trioginal).

Study Results: After 8 weeks of treatment, all women saw the number of Lactobacillus casei var. Rhamnosus Döderlein return to normal, vaginal pH drop from 6.02 ± 0.1 to 4.10 ± 0.1 (p < 0.05), and VHI score increase from 2.1 ± 0.2 to 4.3 ± 0.1 (p < 0.05). Clinical parameters and subjective assessments showed that vaginal dryness, burning, and itching had disappeared, and the intensity of dyspareunia had significantly lessened. No adverse events were reported during this study.

Conclusion: Trioginal helps eliminate the clinical manifestations of vaginal atrophy and improve the quality of life of women using GnRH-a.


T. A. Oboskalova — Ural State Medical University, Ministry of Health of Russia, Ekaterinburg. City Clinical Hospital No. 40, Ekaterinburg. E-mail: oboskalova.tat@yandex.ru

I. V. Lavrentieva — Ural State Medical University, Ministry of Health of Russia, Ekaterinburg. E-mail: lavr6607@bk.ru

O. V. Prokhorova — Ural State Medical University, Ministry of Health of Russia, Ekaterinburg. Pediatric City Hospital No. 10; City Perinatal Center, Ekaterinburg. E-mail: prokhorova-ov@yandex.ru

A. V. Vorontsova — Ural State Medical University, Ministry of Health of Russia, Ekaterinburg. City Clinical Hospital No. 40, Ekaterinburg. E-mail: redaktor@rusmg.ru


Доктор.ру
1 March 00:00
LITERATURE
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  2. Серов В. Н. Терапия урогенитальных расстройств, обусловленных дефицитом эстрогенов // Акушерство, гинекология и репродукция. 2010. № 1. С. 21–35.
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  6. Moroni R. M., Martins W. P., Ferriani R. A., Vieira C. S. et al. Add-back therapy with GnRH analogues for uterine fibroids // Cochrane Database Syst. Rev. 2015. Vol. 3. CD010854.
  7. Parks D. M., Levine J. Helping women understand treatment options for vulvar and vaginal atrophy // Nurs. Womens Health. 2015. Vol. 19. N 4. P. 298–312.
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