ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378
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Menopausal Hormone Therapy and Vascular Events: What is their Relationship?

DOI:10.31550/1727-2378-2018-154-10-51-55
Bibliography link: Kuznetsov M.R., Papysheva O.V. Menopausal Hormone Therapy and Vascular Events: What is their Relationship? Doctor.Ru. 2018; 10(154): 51–55. DOI: 10.31550/1727-2378-2018-154-10-51-55
Menopausal Hormone Therapy and Vascular Events: What is their Relationship?
16 November 09:58

Objective of the Review: To present the basic current information about the effects of menopausal hormone therapy (MHT) on arterial and venous vascular events.

Key Points: The article describes possible vascular risks associated with MHT, including the risk of ischemic heart disease, atherosclerosis, and arterial and venous thrombosis. The following aspects of MHT are viewed as important: the time and mode of administration and the choice of preparation, with regard to its composition (estrogen and gestagen components).

Conclusion: When the age of initiation, treatment regimen, and the composition of preparation are chosen correctly, the positive properties of MHT reduce the risk of cardiovascular events. Administering MHT at an earlier age makes it possible to achieve maximum effectiveness and to minimize potential complications. The right approach to choosing MHT preparations with their modes of administration and composition taken into consideration is required. In terms of cardiovascular risks, optimal MHT preparations are oral medications containing analogs of natural sex hormones. The most preferable estrogen is estradiol, and the best gestagen is dydrogesterone, which has proven beneficial in patients with either venous or arterial abnormalities.


M.R. Kuznetsov — N.I. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow. N.E. Bauman City Clinical Hospital No.29, Moscow City Department of Health. E-mail: mrkuznetsov@mail.ru

O.V. Papysheva — N.E. Bauman City Clinical Hospital No.29, Moscow City Department of Health. E-mail: viulen@mail.ru

Menopausal Hormone Therapy and Vascular Events: What is their Relationship?
16 November 09:58
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