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Non-Contraceptive Effects of Combined Oral Contraceptives Fortified with Calcium Levomefolate

Bibliography link: Dikke G. B., Lebedeva M. G. Non-Contraceptive Effects of Combined Oral Contraceptives Fortified with Calcium Levomefolate. Doctor.Ru. 2017; 9(138): 64–68.
Non-Contraceptive Effects of Combined Oral Contraceptives Fortified with Calcium Levomefolate
16 October 00:00

Objective of the Review: To summarize currently available data about the non-contraceptive effects of combined oral contraceptives (COC) fortified with calcium levomefolate.

Key Points: The paper includes information on the role of folic acid (FA) in human metabolism and its protective cardiovascular effects (through reducing blood homocysteine levels) in patients with polycystic ovary syndrome. Compared to COC without calcium levomefolate, COC containing FA have greater effects on the skin, reducing acne more significantly and providing FA protection against photosensitization. COC with FA have also more marked effects than COC without calcium levomefolate on clinical manifestations of premenstrual syndrome and depression (FA has a neuroprotective effect). Thus, FA potentiates the noncontraceptive effects of drospirenone, resulting from its anti-androgenic and antimineralocorticoid activity.

Conclusion: Fortification of drospirenone-containing COC with calcium levomefolate not only helps to prevent neural tube defects, but also provides additional protection against cardiovascular disorders, increases therapeutic effectiveness as a treatment for PMS, depression, and acne, and improves the health of skin, nails, and hair.

G. B. Dikke — Peoples’ Friendship University of Russia, Moscow. E-mail: galadikke@yandex.ru

M. G. Lebedeva — Peoples’ Friendship University of Russia, Moscow. E-mail: lebedeva1108@rambler.ru


Non-Contraceptive Effects of Combined Oral Contraceptives Fortified with Calcium Levomefolate
16 October 00:00
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