ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Assessment of Pleiotropic Effects of Melatonin When Used for the Treatment of Insomnia in Men with Metabolic Syndrome Who Work in Shifts

Bibliography link: I. S. Dzherieva, N. I. Volkova. Assessment of Pleiotropic Effects of Melatonin When Used for the Treatment of Insomnia in Men with Metabolic Syndrome Who Work in Shifts // Doctor.Ru. 2016; 7(124): 67–72.
12 September 00:00

Study Objective: To evaluate the efficacy and pleiotropic effects of prolonged-release melatonin used to treat insomnia in men with metabolic syndrome who work in shifts.

Study Design: This was a randomized, open-label, controlled study.

Materials and Methods: Group A included 26 men (mean age, 44; CI: 41.6-46.4) with confirmed metabolic syndrome who had worked shifts for more than 6 years. The control group included 23 apparently healthy age-matched men who worked in the daytime.

Study procedures included blood pressure (BP) and electrocardiogram monitoring and measurement of the degree of night-time BP reduction and circadian index. Other study procedures included measurements of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), plasma glucose, and urinary 6-sulphatoxymelatonine and a subjective assessment of night-sleep quality.

Treatment included getting back to a normal sleep schedule and taking enalapril, amlodipine, and atorvastatin. After week 3, patients were randomized to subgroups A1 and A2. In subgroup A1, patients additionally received a 12-week course of prolonged-release melatonin.

Study Results: In group A, 6-sulphatoxymelatonine levels measured at night and at 4 a.m. were lower (р = 0.028 and 0.014, respectively) and those measured in the daytime were higher (p < 0.001) than in the control group. In subgroup А1, a normal sleep schedule was restored (22.5 points; CI: 21.40–23.30), circadian rhythms returned back to normal (night-time BP reduction 14.17%; CI: 14.16–14.74; circadian index 1.35; CI: 1.31–1.39), and TG (1.52 mmol/L; CI: 1.12–1.97) and HDL-C (1.28 mmol/L; CI: 1.18–2.07) also normalized. Waist circumference was reduced (p = 0.035).

Conclusion: Prolonged-release melatonin is an effective sleep medication that produces pleiotropic effects (restoration of normal circadian rhythms and lipid levels and obesity reduction).

I. S. Dzherieva — Rostov State Medical University, Ministry of Health of Russia. E-mail: dgerieva@yandex.ru

N. I. Volkova — Rostov State Medical University, Ministry of Health of Russia. E-mail: n_i_volkova@mail.ru


Доктор.ру
12 September 00:00
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