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Reproductive Profile Assessment of Female Second-Generation Descendants of People Exposed to Radiation after the Nuclear Test of August 29, 1949

Bibliography link: Dudareva Yu. A., Gurieva V. A. Reproductive Profile Assessment of Female Second-Generation Descendants of People Exposed to Radiation after the Nuclear Test of August 29, 1949. Doctor.Ru. 2017; 13(142)—14(143): 57–61.
Reproductive Profile Assessment of Female Second-Generation Descendants of People Exposed to Radiation after the Nuclear Test of August 29, 1949
19 December 00:00

Study Objective: To compare basic reproductive health parameters in females, in relationship to the radiation total effective dose equivalent (TEDE) received by their grandparents after the nuclear test conducted at the Semipalatinsk Test Site on August 29, 1949.

Study Design: This was an analytical, one-stage (cross-sectional) study.

Materials and Methods: The main group consisted of 67 women whose grandparents were exposed to radiation after the nuclear test conducted at the Semipalatinsk Test Site on August 29, 1949. These women were divided into two subgroups: subgroup 1 consisted of 12 women whose ancestors’ maximum TEDE had been 121.2 to 157.1 cSv, and subgroup 2 was made up of 55 women whose ancestors’ total (cumulative) effective dose had been 44.3 to 63.3 cSv. The control group was made up of 53 women. Criteria for inclusion in the control group were that neither they nor their parents or grandparents had lived in areas exposed to radiation.

Study participants underwent physical examination, including assessment of clinical and paraclinical reproductive health parameters, primarily those related to gynecological and obstetric status. Subpopulation profiles of peripheral blood immune cells (CD3+ T-cells, CD4+ T-helpers, and CD8+ cytotoxic T-cells) were studied and phagocytic index was measured. Levels of main proinflammatory cytokines were measured; these included tumor necrosis factor-α (TNFα), interleukin (IL) 1β, and IL6.

Study Results: The study showed a significantly higher prevalence of gynecological disorders in the main group than in the control group, regardless of the TEDE received by the women’s grandparents (234.3 vs. 96.2, respectively; p < 0.05). The most common gynecological disorders in the main group were menstrual disturbances, reproductive disorders, chronic pelvic inflammatory disease, and hormone-dependent disorders. The most common menstrual disturbance was hypomenorrhea (oligomenorrhea or amenorrhea), beginning at the menarche. Participants in the main group experienced the menarche later than their age-matched controls: 13.5 vs.12.7 (р < 0.05).

Cytokine imbalance was most often present in the main group. The rates of abnormal IL-1β and TNFα levels were independent of the radiation dose received by the women’s grandparents. Higher IL-6 levels were, however, more frequently observed in women whose grandparents had received higher TEDE (50.0% vs. 12.7%, respectively; р < 0.05). Cellular immunity dysfunction was found in all women in the main group: levels of cytotoxic T-cells were decreased to 22.4 ± 4.3% and the immunoregulatory ratio was elevated up to 1.9 ± 0.4, which was significantly different from the control group values (р < 0.05 for both comparisons). The main group participants whose grandparents had received higher radiation doses had lower blood levels of cytotoxic T-cells (21.1 ± 4.2% vs. 23.4 ± 3.4%; р < 0.05).

Conclusion: Female second-generation descendants of people exposed to radiation had poorer reproductive health parameters than women living in areas not exposed to radiation. Their health parameters, however, were not particularly affected by the TEDE levels received by their grandparents.


Yu. A. Dudareva — Altai State Medical University, Barnaul. E-mail: julia.dudareva@mail.ru

V. A. Gurieva — Altai State Medical University, Barnaul. E-mail: vgurjeva@yandex.ru

Reproductive Profile Assessment of Female Second-Generation Descendants of People Exposed to Radiation after the Nuclear Test of August 29, 1949
19 December 00:00
LITERATURE
  1. Шойхет Я. Н., Лоборев В. М., Судаков В. В., Гордеев К. И., Лагутин А. А., Киселев В. И.; Шойгу С. К., ред. Последствия радиационного воздействия ядерных испытаний на население Алтайского края и меры по его социальной защите. Барнаул: Азбука; 2003. 411 с. [Shoikhet Ya. N., Loborev V. M., Sudakov V. V., Gordeev K. I., Lagutin A. A., Kiselev V. I.; Shoigu S. K., red. Posledstviya radiatsionnogo vozdeistviya yadernykh ispytanii na naselenie Altaiskogo kraya i mery po ego sotsial'noi zashchite. Barnaul: Azbuka; 2003. 411 s. (in Russian)]
  2. Шойхет Я. Н., Козлов В. А., Коненков В. И., Киселев В. И., Сенников С. В., Колядо И. Б. и др. Иммунная система населения, подвергшегося радиационному воздействию на следе ядерного взрыва. Барнаул; 2000. 179 с. [Shoikhet Ya. N., Kozlov V. A., Konenkov V. I., Kiselev V. I., Sennikov S. V., Kolyado I. B. i dr. Immunnaya sistema naseleniya, podvergshegosya radiatsionnomu vozdeistviyu na slede yadernogo vzryva. Barnaul; 2000. 179 s. (in Russian)]
  3. Гурьева В. А. Состояние здоровья женщин в двух поколениях, проживающих на территории, подвергшейся радиационному воздействию при испытаниях ядерного устройства на Семипалатинском полигоне: Автореф. дис. … докт. мед. наук. СПб.; 1996. 34 с. [Gur'eva V. A. Sostoyanie zdorov'ya zhenshchin v dvukh pokoleniyakh, prozhivayushchikh na territorii, podvergsheisya radiatsionnomu vozdeistviyu pri ispytaniyakh yadernogo ustroistva na Semipalatinskom poligone: Avtoref. dis. … dokt. med. nauk. SPb.; 1996. 34 s. (in Russian)]
  4. Корнев М. Н., Бориско Г. А., Кашина-Ярмак В. Л. Состояние здоровья детей, рожденных в семьях родителей, облученных вследствие аварии на Чернобыльской АЭС. Клин. педиатрия. 2012; 6(41): 66–70. [Kornev M. N., Borisko G. A., Kashina-Yarmak V. L. Sostoyanie zdorov'ya detei, rozhdennykh v sem'yakh roditelei, obluchennykh vsledstvie avarii na Chernobyl'skoi AES. Klin. pediatriya. 2012; 6(41): 66–70. (in Russian)]
  5. Куценко И. Г., Карпов А. Б., Евтушенко И. Д., Тахауов Р. М. К вопросу о влиянии ионизирующего излучения на репродуктивную систему женщин. Здравоохранение Российской Федерации. 2006; 4: 47–51. [Kutsenko I. G., Karpov A. B., Evtushenko I. D., Takhauov R. M. K voprosu o vliyanii ioniziruyushchego izlucheniya na reproduktivnuyu sistemu zhenshchin. Zdravookhranenie Rossiiskoi Federatsii. 2006; 4: 47–51. (in Russian)]
  6. Ширшев С. В. Механизмы иммунно-эндокринного контроля процессов репродукции. Екатеринбург: УрО РАН; 2002. 431 с. [Shirshev S. V. Mekhanizmy immunno-endokrinnogo kontrolya protsessov reproduktsii. Ekaterinburg: UrO RAN; 2002. 431 s. (in Russian)]
  7. Аклеев А. В., Овчарова Е. С. Иммунный статус людей, подвергшихся хроническому радиационному воздействию, в отдаленные сроки. Мед. радиология и радиационная безопасность. 2007; 52(3): 5–9. [Akleev A. V., Ovcharova E. S. Immunnyi status lyudei, podvergshikhsya khronicheskomu radiatsionnomu vozdeistviyu, v otdalennye sroki. Med. radiologiya i radiatsionnaya bezopasnost'. 2007; 52(3): 5–9. (in Russian)]
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