ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378
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Perinatal Outcomes and Vascular Endothelial Growth Factor Levels in Women with Growth-Restricted Fetuses

DOI:10.31550/1727-2378-2018-154-10-18-21
Bibliography link: Ulyanina E.V., Fatkullin I.F., Akhmadeev N.R. Perinatal Outcomes and Vascular Endothelial Growth Factor Levels in Women with Growth-Restricted Fetuses. Doctor.Ru. 2018; 10(154): 18–21. DOI: 10.31550/1727-2378-2018-154-10-18-21
Perinatal Outcomes and Vascular Endothelial Growth Factor Levels in Women with Growth-Restricted Fetuses
16 November 09:27

Study Objective: To identify the value of measuring vascular endothelial growth factor (VEGF) for predicting unfavorable perinatal outcomes in women with growth-restricted fetuses.

Study Design: This was a comparative study.

Materials and Methods: Fifty pairs of women were examined at weeks 22/0 to 39/0 of gestation. The main group was composed of 50 women whose pregnancies were complicated by intrauterine growth restriction (IUGR) of varying severity. The comparison group was made up of 50 pregnant women without this complication, who gave birth to normotrophic preterm or term babies. For purposes of correlation analysis, the women were divided into two subgroups according to the number of weeks of gestation: weeks 22/0 to 29/6 (subgroup I, n = 34, 34.0%) and weeks 30/0 to 39/0 (subgroup II, n = 66, 66.0%). Study procedures included a medical history, clinical examination, cardiotocography, ultrasonography of the fetal-placental-maternal system, and measurement of serum VEGF levels by immunoassay.

Study Results: The study revealed a moderate correlation between VEGF levels and the severity of IUGR in women from subgroup I. Forty-seven patients with diagnosed IUGR (94%) had VEGF of 100 pg/mL or higher (p = 0.0001), regardless of the week of gestation. All cases of antenatal fetal death and early neonatal death were reported in women with VEGF higher than 200 pg/mL (p = 0.0001). In women without IUGR there was no correlation between VEGF levels and the main perinatal complications.

Conclusion: This study confirmed the role of VEGF as an important tool for assessing the risk of stillbirth and early neonatal death.


E.V. Ulyanina — Kazan State Medical University, Russian Ministry of Health. E-mail: ualena87@yandex.ru

I.F. Fatkullin — Kazan State Medical University, Russian Ministry of Health. E-mail: fatkullin@yandex.ru

N.R. Akhmadeev — Kazan State Medical University, Russian Ministry of Health. E-mail: akhmadeyevnr@gmail.com


Perinatal Outcomes and Vascular Endothelial Growth Factor Levels in Women with Growth-Restricted Fetuses
16 November 09:27
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