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Association Between Sleep and Metabolic Disorders in Patients with Polycystic Ovary Syndrome

For citation: Yu. S. Absatarova, E. V. Sheremetieva, E. N. Andreeva. Association Between Sleep and Metabolic Disorders in Patients with Polycystic Ovary Syndrome // Doctor.Ru. 2016; 8(125) — 9(126): 57–62.
15 September 00:00

Study Objective: To study the association between sleep and metabolic disorders in patients with polycystic ovary syndrome (PCOS) and to provide data that would prove the efficacy of using melatonin as part of a combination treatment regimen in this patient population.

Materials and Methods: The study included 60 patients with PCOS and 60 healthy women (control group). At stage I, we selected 30 patients with PCOS and body mass index (BMI) ≥25 kg/m2 (subgroup 1) and 30 patients with PCOS and BMI <25 kg/m2 (subgroup 2). Subgroup 3 included 30 healthy women with BMI ≥25 kg/m2, subgroup 4 consisted of 30 healthy women with BMI <25 kg/m2. All study participants completed a questionnaire specifically designed to assess the severity of sleep disorders. Other study examinations included blood chemistry (glucose and lipid profile) and hormone tests (insulin, luteinizing hormone, follicle-stimulating hormone, and testosterone). In addition, insulin resistance was determined by the Homeostasis Model Assessment. As it was indicated, patients with PCOS received a combined oral contraceptive containing drospirenone, ethinyl estradiol, and calcium levomefolate. They were also given metformin and a synthetic analogue of melatonin.

Study Results: Women with PCOS had significant dyslipidemia, insulin resistance, and hyperandrogenemia. Overall, 70% of patients with BMI <25 kg/m2 had sleep disorders, which tended to correlate in severity with insulin level. Melatonin helped effectively treat sleep disorders.

Conclusion: Polycystic ovary syndrome requires a multidisciplinary approach with an assessment for sleep disorders as an essential component. Such patients require long-term medical follow-up.


Yu. S. Absatarova — Scientific Center of Endocrinology, Moscow. E-mail: korsil2008@yandex.ru

E. V. Sheremetieva — Scientific Center of Endocrinology, Moscow. E-mail: redaktor@rusmg.ru

E. N. Andreeva — Scientific Center of Endocrinology, Moscow. E-mail: redaktor@rusmg.ru

Доктор.ру
15 September 00:00
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