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The Structural and Functional Condition of the Vascular Wall in Young Patients with Premature Ovarian Failure

DOI:10.31550/1727-2378-2018-150-6-44-48
Bibliography link: Ignatieva R. E., Gustovarova T. A., Milyagin V. A., Dmitrieva E. V. The Structural and Functional Condition of the Vascular Wall in Young Patients with Premature Ovarian Failure. Doctor.Ru. 2018; 6(150): 44–48.
The Structural and Functional Condition of the Vascular Wall in Young Patients with Premature Ovarian Failure
10 September 12:31

Study Objective: To study endothelial functionality and vascular elasticity in young patients with premature ovarian failure (POF) before they develop the first clinical signs of cardiovascular disorders.

Study Design: This was a comparative study.

Materials and Methods: Sixty patients with POF (mean age 34.9 ± 0.6) and 50 women with preserved ovarian function (mean age 34.5 ± 0.6) (control group) took part in the study. All study participants underwent physical examination and assessment of their hormonal status, endothelial functionality and vascular elasticity.

Study Results: In the POF group the reflection index (RI), which characterizes the tone of small muscular arteries, was higher than normal and significantly higher than the RI in women with preserved ovarian function: 33.2 ± 1.1% vs. 25.7 ± 0.8%, respectively; p < 0.05. The amplitude occlusion index, which reflects the condition of the endothelium in small arteries and arterioles, was significantly lower in patients with POF than in women with a normal menstrual cycle: 1.69 ± 0.05 vs. 2.34 ± 0.07, respectively; p < 0.05. The phase shift between the channels, which is a characteristic of the endothelial condition of medium-sized muscular arteries, was also significantly lower in women with POF than in women in the control group: 7.8 ± 0.3 ms vs. 11.5 ± 0.4 ms, respectively; p < 0.05.

Conclusion: Patients with POF had early changes in the vascular wall: endothelial dysfunction and increased tone of the small arteries. A new diagnostic technique for women with POF will help identify women with preclinical atherosclerosis, which is an effective preventive strategy for cardiovascular disorders.

R. E. Ignatieva — Smolensk State Medical University. E-mail: raisa.ign@mail.ru

T. A. Gustovarova — Smolensk State Medical University. Clinical Hospital No. 1, Smolensk. E-mail: tanya.prof@yandex.ru

V. A. Milyagin — Smolensk State Medical University. E-mail: terapufd@smolgmu.ru

E. V. Dmitrieva — Smolensk State Medical University. E-mail: vernulas@mail.ru

The Structural and Functional Condition of the Vascular Wall in Young Patients with Premature Ovarian Failure
10 September 12:31
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