Effects of Progesterone and its Analogs on the Functional Status of the Central Nervous System

For citation: I. A. Ilovayskaya, D. S. Mikhaylova, V. Yu. Zektser. Effects of Progesterone and its Analogs on the Functional Status of the Central Nervous System // Doctor.Ru. 2016; 7(124): 73–77.
12 September 00:00

Objective of the Review: to discuss the effect of progesterone and some of its synthetic analogs on functioning of the central nervous system (CNS).

Key Points: Neurosteroid effects of the endogenous progesterone include sedative, anxiolytic, anticonvulsant and analgesic ones. The progesterone affects the brain by activating specific progesterone receptors that are widely distributed in CNS tissues. Progesterone protects CNS cells from physical and chemical damage, including brain trauma. Besides, progesterone derivatives (such as allopregnanolone and pregnenolone) have an intrinsic protective effect. Effects of synthetic progestins on the CNS differ from the profile of the endogenous progesterone, and this difference may be clinically significant.

Conclusion: Multiple experimental and clinical data indicate various effects of progesterone on brain cells. The fact that progesterone and synthetic progestins influence the CNS differently should be taken into account when choosing a gestagen component of hormonal therapy.

I. A. Ilovayskaya — M. F. Vladimirskiy Moscow Regional Research and Clinical Institute. E-mail: irena.ilov@yandex.ru

D. S. Mikhaylova — M. F. Vladimirskiy Moscow Regional Research and Clinical Institute. E-mail: d.s.mikhaylova@mail.ru

V. Yu. Zektser — I. M. Sechenov First Moscow State Medical University. E-mail: zektservita@mail.ru

12 September 00:00
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