A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Idiopathic Pancreatitis and Cystic Fibrosis

DOI:10.31550/1727-2378-2019-163-8-18-27
For citation: Gubergritz N.B., Monogarova N.E., Belyaeva N.V., Fomenko P.G., Burka A.A., Zeinalova A.A. Idiopathic Pancreatitis and Cystic Fibrosis. Doctor.Ru. 2019; 8(163): 18–27. (in Russian) DOI: 10.31550/1727-2378-2019-163-8-18-27
23 august 2019

Objective: to describe the current information on idiopathic pacreatitis (IP) and cystic fibrosis (CF).

Key Points. The article contains information about IP, and the diagnostic algorithm to find out the root cause of the disease is described. The aetiology, nosotropic mechanisms of CF occurrence, known CFTR gene mutations affecting the course of the disease, as well as the principles of enzyme replacement therapy for patients with CF are discussed. The data from evidence-based medicine are presented which confirm the efficiency and safety of pancreatin-containing enzyme drugs for the management of exocrine pancreatic insufficiency.

Conclusion. The heavy growth of the medical science brings about new information on the causes and initiation of genetic disorders, and gives new knowledge on possible therapeutic and gene management, improving the quality and length of life of patients, including patients with CF.

Contribution: Gubergritz, N.B. — article idea and reviewing; Monogarova, N.E. — description of extrapulmonary cystic fibrosis manifestations; Belyaeva, N.V. — analysis of causes of idiopathic pancreatitis; Fomenko, P.G. — literary review and article compilation; Burka, A.A. — analysis of gene mutations causing cystic fibrosis; Zeinalova, A.A. — description of pulmonary cystic fibrosis manifestations.

Conflict of interes: The authors declare that they do not have any conflict of interests.

N.B. Gubergritz — M. Gorky Donetsk National Medical University; 27 Privokzalnaya Str., Liman, Donetsk Region, Ukraine 84404. ORCID: http://orcid.org/0000-0003-3655-9554. E-mail: profnbg@ukr.net

N.E. Monogarova — M. Gorky Donetsk National Medical University; 16 Ilyich Avenue, Donetsk, Ukraine 83003. E-mail: fakultetskaya-terapia@dnmu.ru

N.V. Belyaeva — M. Gorky Donetsk National Medical University; 27 Privokzalnaya Str., Liman, Donetsk Region, Ukraine 84404. E-mail: 771984@gmail.com

P.G. Fomenko — M. Gorky Donetsk National Medical University; 16 Ilyich Avenue, Donetsk, Ukraine 83003. E-mail: fomenko_pg@mail.ru

A.A. Burka — Municipal Children’s Hospital No. 38 of the Moscow Department of Health; 2 10-letiya Oktyabrya Str., Moscow, Russian Federation 117036. E-mail: burka@dr.com

A.A. Zeinalova — M. Gorky Donetsk National Medical University; 16 Ilyich Avenue, Donetsk, Ukraine 83003. E-mail: fakultetskaya-terapia@dnmu.ru


Доктор.ру
23 August 22:28
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