ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Chronic Noninfectious Diseases after Liver Transplantation

DOI:10.31550/1727-2378-2019-163-8-44-48
Bibliography link: Kosmacheva E.D., Babich A.E. Chronic Noninfectious Diseases after Liver Transplantation. Doctor.Ru. 2019; 8(163): 44–48. (in Russian) DOI: 10.31550/1727-2378-2019-163-8-44-48
23 August 12:31

Study Objective: To evaluate the prevalence of various chronic noninfectious diseases in liver transplant recipients.

Study Design: This was a retrospective study of regional registry data.

Materials and Methods: The study was performed on the data of 132 patients who had undergone orthotopic liver transplantation at the Professor S.V. Ochapovsky Territorial Clinical Hospital No. 1 Research Institute (a Government-funded Healthcare Institution), Ministry of Health of Krasnodar Region, between February 2016 and May 2019. Data extracted from hospital records and office charts were analyzed. The prevalence of diseases before the transplantation and four years after it was compared.

Study Results: Before transplantation systolic blood pressure of 140 mm Hg or higher was reported in 17 out of 45 patients (37.8%) and after transplantation it was observed in 28 out of 45 patients (62.2%). Before transplantation chronic pancreatitis was diagnosed in 33.3% of the patients, and after transplantation it was reported in 65.2% of the cases. The prevalence of erosive gastritis was reduced by 3%, and that of gastroesophageal reflux disease increased by 13.7%. The prevalence of coronary artery disease and chronic heart failure increased by 28.0% and 21.2%, respectively.

Conclusion: Our data, showing an increased prevalence of some diseases, including those influencing cardiovascular morbidity, in liver transplant recipients suggest that practitioners should focus their efforts not only on preventing acute transplant rejection, but also on identifying risk factors for chronic noninfectious diseases. Transplant centers need to develop a special follow-up protocol for liver transplant recipients.

Contribution: Kosmacheva, E.D. — study design, review of critically important material, approval of the article for publication; Babich, A.E. — a set of clinical material, data processing analysis and interpretation, article preparation.

Conflict of interes: The authors declare that they do not have any conflict of interests.

E.D. Kosmacheva — Professor S.V. Ochapovsky Territorial Clinical Hospital No. 1 Research Institute (a Government-funded Healthcare Institution), Ministry of Health of Krasnodar Region; 167 Pervogo Maya St., Krasnodar, Russian Federation 350086. eLIBRARY.RU SPIN: 5277-2982. E-mail: kosmachova_h@mail.ru

A.E. Babich — Professor S.V. Ochapovsky Territorial Clinical Hospital No. 1 Research Institute (a Government-funded Healthcare Institution), Ministry of Health of Krasnodar Region; 167 Pervogo Maya St., Krasnodar, Russian Federation 350086. eLIBRARY.RU SPIN: 2417-7122. E-mail: anna-babich1@yandex.ru

Доктор.ру
23 August 12:31
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