ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Chronic Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: a Unique Duality

Bibliography link: Reyzis A. R., Borzakova S. N. Chronic Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: a Unique Duality. Doctor.Ru. 2017; 12(141): 24–29.
14 November 00:00

Objective of the Review: To raise the level of awareness among researchers and practitioners about the comorbidity of inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC).

Key Points: Based on currently available data, it has been suggested that these conditions, which are mutually exacerbating, especially with respect to conversion to malignancy, be viewed as a dual systemic disorder. Diagnosis of PSC in patients with IBD, as well as the opposite case — detection of IBD in patients with PSC, are extremely challenging and require a thorough targeted examination. Classical treatments, including surgeries such as colectomy or liver transplant, not only fail to improve the situation, but also not infrequently contribute to development of the related condition de novo. At present, preparations containing ursodeoxycholic acid (UDCA) (Ursosan and others) are the only treatment that alleviates this dual condition and reduces the risk of malignancy (colorectal adenoma and cholangiocarcinoma).

Conclusion: For patients with IBD, early detection of concomitant PSC, which is often present as a subclinical disease for a long time, is critically important for the prognosis. Timely initiation of long-term treatment with UDCA medicines improves quality of life and biochemical parameters and reduces the histological activity of the disease process in both the biliary system and the gastrointestinal tract. It may also reduce the rate of conversion of both of these comorbid disorders to malignancy and increase life expectancy.


A. R. Reyzis — Central Research Institute of Epidemiology, Moscow. E-mail: bobandara@mail.ru

S. N. Borzakova — N. I. Pirogov Russian National Research Medical University, Moscow. E-mail: abbsnb@mail.ru


Доктор.ру
14 November 00:00
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