ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Incidence of Nonalcoholic Fatty Liver Disease in Outpatient Patients in Krasnodar

DOI:10.31550/1727-2378-2018-151-7-25-29
For citation: Eliseeva L. N., Bolotova E. V. Incidence of Nonalcoholic Fatty Liver Disease in Outpatient Patients in Krasnodar. Doctor.Ru. 2018; 7(151): 25–29.
10 October 12:12

Study Objective: To assess the incidence of nonalcoholic fatty liver disease (NAFLD) in outpatient patients in Krasnorad with clinical signs of suspected fatty liver disease caused by reasons other than alcohol addiction; to identify the most important risk factors (RF) of NAFLD.

Study Design: Epidemiological observational cross-over multi-centre study within the scope of DIREG 2 multi-centre study.

Materials and Methods: The work was performed in outpatient clinics in Krasnodar. Researchers were 55 qualified medical experts (GPs and gastroenterologists).The study included 3,255 patients who were screened for criteria of inclusion/ exclusion (presence/ absence of RFs).Epidemiological data were obtained during two visits of patients to the study centres.

Study Results: NAFLD risk factors in the population of Krasnodar were observed in 90.6% of patients. Both in male and female population the main RF is BWI of ≥ 27 kg/m2; besides the leading role in both sex groups was assigned to arterial hypertension, hypertriglyceridemia, type 2 diabetes mellitus, and metabolic syndrome.

The overall NAFLD incidence in patients with suspected NAFLD was 51.78%; the ratio of cirrhotic and non-cirrhotic forms of nonalcoholic hepatic diseases in the studied and screened population is 1 :72.6 (1.4% and 98.6%, respectively).

Conclusion: The results of the study show high incidence of NAFLD in Krasnodar. Special attention paid to NAFLD RFs will allow enhancing the efficiency of screening, saving human and material resources in health care, and individualising hepatoprotective prescriptions.

L. N. Eliseeva — Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar. E-mail: yeliseyeva@mail.ru

E. V. Bolotova — Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar. E-mail: bolotowa_e@mail.ru

Доктор.ру
10 October 12:12
LITERATURE
  1. Chalasani N., Younossi Z., Lavine J.E. The diagnosis and management of nonalcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology and the American Gastroenterological Association. Hepatology. 2012; 55: 2005–23. DOI: 10.1002/hep.25762.
  2. Драпкина О. М., Ивашкин В. Т. Эпидемиологические особенности неалкогольной жировой болезни печени в России. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2014; 4: 32–8. [Drapkina O.M., Ivashkin V.T. Epidemiologicheskie osobennosti nealkogol'noi zhirovoi bolezni pecheni v Rossii. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2014; 4: 32–8. (in Russian)]
  3. Drapkina O., Evsyutina Y., Ivashkin V. Prevalence of nonalcoholic fatty liver disease in the Russian Federation: the open, multicenter, prospective study, DIREG 1. American Journal of Clinical Medicine Research. 2015; 3(2): 31–6.
  4. Елисеева Л. Н., Бледнова А. Ю., Бочарникова М. И., Самородская Н. А. Неалкогольная жировая болезнь печени и маркеры сердечно-сосудистой патологии. Российские медицинские вести. 2010; 15 (1): 47–53. [Eliseeva L.N., Blednova A.Yu., Bocharnikova M.I., Samorodskaya N.A. Nealkogol'naya zhirovaya bolezn' pecheni i markery serdechno-sosudistoi patologii. Rossiiskie meditsinskie vesti. 2010; 15 (1): 47–53. (in Russian)]
  5. Цуканов В. В., Тонких Ю. Л., Каспаров Э. В., Куперштейн Е. Ю., Амельчугова О. С., Лукичева Э. В. и др. Неалкогольная жировая болезнь печени у взрослого городского населения России (Распространенность и факторы риска). Врач. 2010; 9: 1–4. [Tsukanov V.V., Tonkikh Yu.L., Kasparov E.V., Kupersh­tein E.Yu., Amel'chugova O.S., Lukicheva E.V. i dr. Nealkogol'naya zhirovaya bolezn' pecheni u vzroslogo gorodskogo naseleniya Rossii (Rasprostranennost' i faktory riska). Vrach. 2010; 9: 1–4. (in Russian)]
  6. Елисеева Л. Н., Будашова Т. М., Долганова Т. Ю., Бочарникова М. И. Особенности выявления неалкогольной жировой болезни печени в клинической практике. Российские медицинские вести. 2009; 14 (1): 31–6. [Eliseeva L.N., Budashova T.M., Dolganova T.Yu., Bocharnikova M.I. Osobennosti vyyavleniya nealkogol'noi zhirovoi bolezni pecheni v klinicheskoi praktike. Rossiiskie meditsinskie vesti. 2009; 14 (1): 31–6. (in Russian)]
  7. Toplak H., Stauber R., Sourij H. EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease: guidelines, clinical reality and health economic aspects. Diabetologia. 2016; Apr 7. DOI: 10.1007/s00125-016-3941-4.
  8. Ивашкин В. Т., Драпкина О. М., Маев И. В., Трухманов А. С., Блинов Д. В., Пальгова Л. К. и др. Распространенность неалкогольной жировой болезни печени у пациентов амбулаторно-поликлинической практики в Российской Федерации: результаты исследования DIREG 2. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2015; 6: 31–41. [Ivashkin V.T., Drapkina O.M., Maev I.V., Trukhmanov A.S., Blinov D.V., Pal'gova L.K. i dr. Rasprostranennost' nealkogol'noi zhirovoi bolezni pecheni u patsientov ambulatorno-poliklinicheskoi praktiki v Rossiiskoi Federatsii: rezul'taty issledovaniya DIREG 2. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2015; 6: 31–41. (in Russian)]
  9. Елисеева Л. Н., Долганова Т. Ю., Кривцун Е. А., Васинова Ю. В., Малхасян И. Г. Неалкогольная жировая болезнь печени в практике участкового терапевта, эпидемиологический анализ и этиопатогенетические взаимосвязи. Гастроэнтерология Юга России. Ростов-на-Дону, 2009. C. 48–52. [Eliseeva L.N., Dolganova T.Yu., Krivtsun E.A., Vasinova Yu.V., Malkhasyan I.G. Nealkogol'naya zhirovaya bolezn' pecheni v praktike uchastkovogo terapevta, epidemiologicheskii analiz i etiopatogeneticheskie vzaimosvyazi. Gastroenterologiya Yuga Rossii. Rostov-na-Donu; 2009. C. 48–52. (in Russian)]
  10. Долганова Т. Ю., Елисеева Л. Н., Малхасян И. Г., Васинова Ю. В. Особенности поражения печени у пациентов, обращающихся в поликлинику по другим причинам. Материалы II международной конференции «Человек и природа. Проблемы экологии Юга России». Тамань–Краснодар, 5–8 сентября 2008 г. Краснодар; 2008: 116–18. [Dolganova T.Yu., Eliseeva L.N., Malkhasyan I.G., Vasinova Yu.V. Osobennosti porazheniya pecheni u patsientov, obrashchayushchikhsya v polikliniku po drugim prichinam. Materialy II mezhdunarodnoi konferentsii "Chelovek i priroda. Problemy ekologii Yuga Rossii". Taman'–Krasnodar, 5–8 sentyabrya 2008 g. Krasnodar, 2008: 116–18. (in Russian)]
  11. Zezos P., Renner E. L. Liver transplantation and non-alcoholic fatty liver disease. World J. Gastroenterol. 2014; 20(42): 15532–38. DOI: 10.3748/wjg.v20.i42.15532.
  12. Edmunds L., Otero P.A., Sharma L., D’Souza S., Doleza J.M., David S. et al. Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes // Oncotarget. 2016; 7: 30379–95. DOI: 10.18632/oncotarget.8856.

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