A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Secondary Lactase Deficiency and Impact of Small-Intestinal Microflora on Electrical and Motor Activity of Intestinal Smooth Muscles

27 february 2015

Study Objectives: To investigate 1) the electrical and motor activity of small-intestine and colonic smooth muscles in patients with secondary lactase deficiency (SLD) and 2) the impact of small-intestinal microflora on intestinal-propulsive activity.

Materials and Methods: We examined 93 patients with SLD and evaluated their small-intestine microbiota (hydrogen breath test) and the activity of intestinal smooth muscles.

Study Results: Clinically, moderate SLD is manifested as persistent flatulence. It is caused by small-intestinal hypomotility, which is worsened by bacterial overgrowth. Breath hydrogen was 86.9 ± 20.9 ppm in patients with moderate SLD аnd 105.3 ± 28.3 ppm in patients with severe SLD. The clinical picture of severe SLD was dominated by diarrhea caused by intestinal hypermotility. In most patients with moderate SLD, a 14-day treatment course of probiotic led to a disease's remission and helped restore intestinal motility and eubiotic microflora.

I. N. Ruchkina — Moscow Clinical Scientific and Practical Center at the Moscow Department of Healthcare. E-mail: ruchkinai@mail.ru

A. E. Lychkova — Moscow Clinical Scientific and Practical Center at the Moscow Department of Healthcare. E-mail: lychkova@mail.ru

N. A. Fadeeva — Moscow Clinical Scientific and Practical Center at the Moscow Department of Healthcare. E-mail: chuevana@mail.ru

P. L. Shcherbakov — Moscow Clinical Scientific and Practical Center at the Moscow Department of Healthcare. E-mail: p.sherbakov@mknc.ru

O. V. Knyazev — Moscow Clinical Scientific and Practical Center at the Moscow Department of Healthcare. E-mail: o.knyazev@mknc.ru

Доктор.ру
27 February 11:08
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