The Role of Vitamin D in Reproduction № 10 (154), 2018
1 D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine, St. Petersburg
2 I.I. Mechnikov Northwestern State Medical University, Russian Ministry of Health, St. Petersburg
Objective of the Review: A systematic analysis of recently published data on the role of vitamin D in the regulation of steroidogenesis and folliculogenesis and in the development of hormonal disorders accompanying various gynecological diseases.
Key Points: This review includes data from relevant Russian and foreign papers found in bibliographical electronic databases. It describes specific aspects of vitamin D metabolism and its relationship with steroidogenesis in the ovaries. The authors highlight a variety of vitamin D functions performed through genomic and non-genomic mechanisms and the possible involvement of this vitamin in the epigenetic and allosteric regulation of steroidogenesis and folliculogenesis. They also explore the possible role of vitamin D deficiency in the development of hormonal disorders in patients with polycystic ovary syndrome or endometriosis. The review cites evidence-based approaches to the diagnosis and treatment of vitamin D deficiency.
Conclusion: Elimination of vitamin D deficiency may be an important step in a comprehensive treatment program for women of reproductive age with diseases causing normogonadotropic anovulation.
For reference: Abashova E.I., Yarmolinskaya M.I., Misharina E.V. The Role of Vitamin D in Reproduction. Doctor.Ru. 2018; 10(154): 37–42. DOI: 10.31550/1727-2378-2018-154-10-37-42
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