Use of Anticoagulation Therapy in Assisted-Reproductive Technologies

1 June 11:37

Objective of the Review: TTo summarize the use of low-molecular heparins, based on international guidelines, and to describe the possible mechanisms underlying the positive effects of heparin as an agent facilitating implantation.

Key Points: This review focuses on the pathogenic pathways that underlie the changes in hemostasis that accompany ovarian stimulation and the association between hemostasis disturbances and adverse perinatal outcomes. The review includes international guidelines on the use of anticoagulants in assisted-reproductive technologies and describes the possible regulatory effects of heparin on hemostasis responses associated with the migration and implantation of fertilized eggs, embryo development and, thus, with assisted-reproductive techniques.

Conclusion: Today, the use of anticoagulants in patients undergoing assisted-reproductive technologies should be based on current international guidelines. Heparin increases the pregnancy rate in women with a history of repeated in-vitro-fertilization failures and thrombophilia. However, further studies are required to confirm these potential effects of heparin (including its low-molecular-weight fractions).

A. V. Murashko — I. M. Sechenov First Moscow State Medical University. E-mail: murashkoa@mail.ru

A. A. Murashko — I. M. Sechenov First Moscow State Medical University. E-mail: redaktor@rusmg.ru

1 June 11:37
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