ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Efficacy and Safety of Follitropin Preparations in In-Vitro-Fertilization Cycles

1 June 11:58

Study Objective: To compare the efficacy and safety of two follitropin alfa preparations (Follitrope and Gonal-F) when used for controlled ovarian stimulation in assisted-reproductive technology (ART) programs in infertile female patients.

Study Design: This was a double-blind, prospective, randomized study.

Materials and Methods: The study included 50 infertile female patients who were candidates for ovarian hyperstimulation as part of ART programs. Patients were stratified into two groups, depending on the preparation used for controlled ovarian stimulation: Follitrope in Group I (n = 25) and Gonal-F in Group II (n = 25). Both preparations were used at a starting dose of 150–225 IU between Day 2 of the menstrual cycle and trigger shot. During the stimulation period, the doses varied, ranging from 75 to 300 IU, depending on the changes in ovarian response. In all cases, stimulation was done using similar protocols with gonadotropin-releasing hormone antagonists.

Study Results: Follitrope and Gonal-F showed different results: The mean duration of ovarian stimulation in in-vitro-fertilization (IVF) programs was significantly shorter in the Follitrope group than in the Gonal-F group, while a daily dose was significantly higher in the Follitrope group, but a total dose was similar. In addition, women who were given Follitrope had fewer growing follicles than those who received Gonal-F. The efficacy of IVF cycles was not significantly different. No side effects or allergic reactions were reported in either group.

Conclusion: Follitrope and Gonal-F are safe follicle-stimulating agents with high comparable clinical efficacy.

N. V. Bashmakova — Ural Research Institute for Maternity and Child-Care Support, Ekaterinburg. E-mail: omm@niiomm.ru

D. O. Mazurov — Ural Research Institute for Maternity and Child-Care Support, Ekaterinburg. E-mail: dmazurov@mail.ru

O. V. Tchermyaninova — Ural Research Institute for Maternity and Child-Care Support, Ekaterinburg. E-mail: helgakuz@yandex.ru

Yu. N. Kozhekina — Ural Research Institute for Maternity and Child-Care Support, Ekaterinburg. E-mail: yunima@mail.ru

Доктор.ру
1 June 11:58
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