ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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The Effectiveness of In Vitro Fertilization Programs in Patients with Low Anti-Müllerian Hormone Levels

DOI:10.31550/1727-2378-2018-154-10-7-9
Bibliography link: Protopopova N.V., Dudakova V.N., Druzhinina E.B., Labygina A.V., Boldonova N.A., Krylova K.V. The Effectiveness of In Vitro Fertilization Programs in Patients with Low Anti-Müllerian Hormone Levels. Doctor.Ru. 2018; 10(154): 7–9. DOI: 10.31550/1727-2378-2018-154-10-7-9
16 November 09:25

Study Objective: To assess the effectiveness of in vitro fertilization (IVF) programs in women from various reproductive age groups with anti-Müllerian hormone (AMH) of 0.9 ng/mL or less.

Study Design: This was a retrospective study.

Materials and Methods: Retrospective analysis was done of 95 IVF programs in which women with AMH of 0.9 ng/mL or less took part. The women were from three age groups: Group I consisted of 47 women aged 34 or younger; Group II had 27 patients aged 35 to 39; and Group III had 21 patients aged 40 or older. Study parameters included embryo assessment, pregnancy rate, and poor response to ovarian stimulation.

Study Results: In the overall study sample of women with low AMH levels, there was a high rate of embryo transfer cancellation in IVF programs, the reason for which in 61.8% of the cases was the absence of oocytes. Pregnancy rates per embryo transfer were higher to a statistically significant degree (р<0.05) in patients aged 34 or younger (21.4%) than in older patients (13.6% and 9.1% in the second and third groups, respectively). None of the women aged 35 or older had deliveries; all pregnancies in this group ended in the early stages.

Conclusion: In patients aged 34 or younger, with AMH levels of 0.9 ng/mL or less, transfer is justified only for embryos of the highest quality. In women of late reproductive age with low AMH levels, the basic IVF protocol should not be used due to its known ineffectiveness.


N.V. Protopopova — Irkutsk State Medical Academy of Postgraduate Education, a branch of the Russian Medical Academy of Continuing Professional Education, Russian Ministry of Health. Irkutsk Regional Clinical Hospital. E-mail: doc_protopopova@mail.ru

V.N. Dudakova — Irkutsk State Medical Academy of Postgraduate Education, a branch of the Russian Medical Academy of Continuing Professional Education, Russian Ministry of Health. E-mail: Vidun@mail.ru

E.B. Druzhinina — Irkutsk State Medical Academy of Postgraduate Education, a branch of the Russian Medical Academy of Continuing Professional Education, Russian Ministry of Health. Irkutsk Regional Clinical Hospital. E-mail: ebdru@mail.ru

A.V. Labygina — Scientific Center for Family Health and Human Reproduction, Irkutsk. E-mail: albinalab2212@mail.ru

N.A. Boldonova — Irkutsk Regional Clinical Hospital. E-mail: nata-doc-712@mail.ru

K.V. Krylova — Irkutsk State Medical Academy of Postgraduate Education, a branch of the Russian Medical Academy of Continuing Professional Education, Russian Ministry of Health. E-mail: Aksy12@mail.ru

Доктор.ру
16 November 09:25
LITERATURE
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  2. Van Rooij I.A.J., Broekmans F.J.M., te Velde E.R., Fauser B.C., Bancsi L.F., de Jong F.H. et. al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum. Reprod. 2002; 17(12): 3061–71
  3. Боярский К.Ю. Роль показателей овариального резерва при лечении бесплодия ЭКО и ПЭ. В кн.: Кулаков В.И., Леонов Б.В., Кузьмичев Л.Н., ред. Лечение женского и мужского бесплодия. Вспомогательные репродуктивные технологии. М.; 2005: 53–61. [Boyarskii K.Yu. Rol' pokazatelei ovarial'nogo rezerva pri lechenii besplodiya EKO i PE. V kn.: Kulakov V.I., Leonov B.V., Kuz'michev L.N., red. Lechenie zhenskogo i muzhskogo besplodiya. Vspomogatel'nye reproduktivnye tekhnologii. M.; 2005: 53–61. (in Russian)]
  4. Mettler L., Salmassi A., Branderburg A., Brandenburg A., Lutzewitch N. Non-responsive patients: characteristic of patients. Fertil. Steril. 1995; 65(2): 361–7
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