ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Risk Factors for Severe Menopausal Syndrome: a Clinicostatistical Study

Bibliography link: Kostromina A. A., Radzinsky V. E., Khamoshina M. B., Soyunov M. A., Ryabova V. A. Risk Factors for Severe Menopausal Syndrome: a Clinicostatistical Study. Doctor.Ru. 2017; 9(138): 12–16.
16 October 00:00

Study Objective: To identify risk factors for severe menopausal syndrome in women during the menopause transition and early postmenopause.

Study Design: This was a prospective, observational, clinicostatistical study.

Materials and Methods: The study included 193 women, aged 45 to 59, during the menopause transition or early postmenopause, who had various signs of menopausal syndrome. Severity of menopausal syndrome was assessed using the modified Kupperman Index. The patients were stratified into three groups by severity of menopausal syndrome: mild (12-34 points, n = 33), moderate (35-58 points, n = 128), and severe (> 58 points, n = 32).

A proprietary questionnaire was used to create a dataset for clinicostatistical analysis. Statistical analysis of the study data was done using Statistica 10 software. The Spearman correlation coefficient and the odds ratio (OR) were calculated.

Study Results: For women during the menopause transition and early postmenopause, risk factors for severe menopausal syndrome included having a secondary but no higher education and moderate income (OR 5.25; 95% CI: 1.8-15.3 for both factors), smoking (OR 5.3; 95% CI: 1.8-15.3), abstinence from alcohol (OR 22.0; 95% CI: 5.4-89.4), and low physical activity (OR 17.9; 95% CI: 4.6-69.7). In women with endocrine disorders (diabetes or metabolic syndrome) or ischemic heart disease, the frequency of severe menopausal syndrome was higher by a factor of 2.1 (p < 0.001 for both parameters). A correlation was also observed between the degree of obesity and severity of menopausal syndrome (r = 0.75).

Conclusion: These data may be used to tailor individual prevention protocols used to protect women's health during the menopause transition and early postmenopause.

A. A. Kostromina — Peoples’ Friendship University of Russia, Moscow. E-mail: nancy1808@mail.ru

V. E. Radzinsky — Peoples’ Friendship University of Russia, Moscow. E-mail: radzinsky@mail.ru

M. B. Khamoshina — Peoples’ Friendship University of Russia, Moscow. E-mail: khamoshina@mail.ru

M. A. Soyunov — Peoples’ Friendship University of Russia, Moscow. E-mail: msoiunov@mail.ru

V. A. Ryabova — Institute of General Pathology and Pathophysiology, Moscow. E-mail: mikhe-valentina@yandex.ru


Доктор.ру
16 October 00:00
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