Enteric and Vaginal Microbiocenosis and Implications for Female Reproductive Health

For citation: Kupina A.D., Petrov Yu.A., Ozdoeva I.M. Enteric and Vaginal Microbiocenosis and Implications for Female Reproductive Health. Doctor.Ru. 2021; 20(1): 73–77. (in Russian). DOI: 10.31550/1727-2378-2021-20-1-73-77
12 March 09:06

Objective of the Review: To analyse Russian and foreign literature concerning the current knowledge of the relations between the reproductive system and gastrointestinal tract (GIT) microbiota and gynaecological disorders, and gestational complications.

Key Points. This review presents current studies of the relations between reproductive system and GIT microbiota. It describes the mechanisms of enteric microflora significance for gynaecological disorders. The role of disturbed vaginal and enteric microbiocenosis in endometriosis and pelvic inflammations is explained. Also, we present the information on the changes in the GIT microbiota in women with premature delivery and describe available information on the mutual formation of vaginal and enteric microbiota.

Conclusion. Qualitative and quantitative disturbances of enteric microbiota result in modified urinogenital microbiocenosis. Microflora alternations in women with endometriosis lead to absence of Atopobium in vaginal and cervical microbiota, increase in Gardnerella in vaginal microbiota, and prevalence of Escherichia and Shigella. Manifestations of disturbed microbiocenosis during pregnancy terminated with premature birth are reduced Clostridium XVIII and IV clusters, XIVa subcluster, and Bacteroides in faecal microbiota. Women with non-specific vulvovaginitis demonstrate high enteric microflora levels (Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus mirabilis, Morganella morganii, etc.) in vulva and vaginal mucosa. Therefore, measures should aim at restoration of enteric and reproductive microbiocenosis as a therapy for gynaecological diseases and obstetrical complications.

Contributions: Kupina, A.D. — selection of the area of the review, search for literature sources, text of the article; Petrov, Yu.A. — objective and aims of the review, academic postediting, approval of the manuscript for publication; Ozdoeva, I.M. — objective and aims of the review, search for literature sources.

Conflict of interest: The authors declare that they do not have any conflict of interests.

A.D. Kupina — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0003-1676-4649. E-mail: anastasyal997@bk.ru

Yu.A. Petrov (Corresponding author) — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0002-2348-8809. E-mail: mr.doktorpetrov@mail.ru

I.M. Ozdoeva — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0002-1283-6601. E-mail: Izabella.ozdoeva97@mail.ru


Received: 02.12.2020
Accepted: 12.01.2021

12 March 09:06
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