A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
Ru
En

Enteric and Vaginal Microbiocenosis and Implications for Female Reproductive Health

DOI:10.31550/1727-2378-2021-20-1-73-77
For citation: Kupina A.D., Petrov Yu.A., Ozdoeva I.M. Enteric and Vaginal Microbiocenosis and Implications for Female Reproductive Health. Doctor.Ru. 2021; 20(1): 73–77. (in Russian). DOI: 10.31550/1727-2378-2021-20-1-73-77
12 March 09:06

Objective of the Review: To analyse Russian and foreign literature concerning the current knowledge of the relations between the reproductive system and gastrointestinal tract (GIT) microbiota and gynaecological disorders, and gestational complications.

Key Points. This review presents current studies of the relations between reproductive system and GIT microbiota. It describes the mechanisms of enteric microflora significance for gynaecological disorders. The role of disturbed vaginal and enteric microbiocenosis in endometriosis and pelvic inflammations is explained. Also, we present the information on the changes in the GIT microbiota in women with premature delivery and describe available information on the mutual formation of vaginal and enteric microbiota.

Conclusion. Qualitative and quantitative disturbances of enteric microbiota result in modified urinogenital microbiocenosis. Microflora alternations in women with endometriosis lead to absence of Atopobium in vaginal and cervical microbiota, increase in Gardnerella in vaginal microbiota, and prevalence of Escherichia and Shigella. Manifestations of disturbed microbiocenosis during pregnancy terminated with premature birth are reduced Clostridium XVIII and IV clusters, XIVa subcluster, and Bacteroides in faecal microbiota. Women with non-specific vulvovaginitis demonstrate high enteric microflora levels (Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus mirabilis, Morganella morganii, etc.) in vulva and vaginal mucosa. Therefore, measures should aim at restoration of enteric and reproductive microbiocenosis as a therapy for gynaecological diseases and obstetrical complications.

Contributions: Kupina, A.D. — selection of the area of the review, search for literature sources, text of the article; Petrov, Yu.A. — objective and aims of the review, academic postediting, approval of the manuscript for publication; Ozdoeva, I.M. — objective and aims of the review, search for literature sources.

Conflict of interest: The authors declare that they do not have any conflict of interests.

A.D. Kupina — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0003-1676-4649. E-mail: anastasyal997@bk.ru

Yu.A. Petrov (Corresponding author) — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0002-2348-8809. E-mail: mr.doktorpetrov@mail.ru

I.M. Ozdoeva — Rostov State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 29 Nakhichevansky Pereulok, Rostov-on-Don, Russian Federation 344022. https://orcid.org/0000-0002-1283-6601. E-mail: Izabella.ozdoeva97@mail.ru

Доктор.ру

Received: 02.12.2020
Accepted: 12.01.2021

12 March 09:06
LITERATURE
  1. Hold G.L., Smith B., Grange C. et al. Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J. Gastroenterol. 2014; 20(5): 1192–210. DOI: 10.3748/wjg.v20.i5.1192
  2. Conlon M.A., Bird A.R. The impact of diet and lifestyle on gut microbiota and human health. Nutrients. 2014; 7(1): 17–44. DOI: 10.3390/nu7010017
  3. Arvonen M., Berntson L., Pokka T. et al. Gut microbiota-host interactions and juvenile idiopathic arthritis. Pediatr. Rheumatol. Online J. 2016; 14(1): 44. DOI: 10.1186/s12969-016-0104-6
  4. Pärtty A., Kalliomäki M., Wacklin P. et al. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatr. Res. 2015; 77(6): 823–8. DOI: 10.1038/pr.2015.51
  5. Zhuang Z.-Q., Shen L.-L., Li W.-W. et al. Gut microbiota is altered in patients with Alzheimer's disease. J. Alzheimers Dis. 2018; 63(4): 1337–46. DOI: 10.3233/JAD-180176
  6. von Theobald P., Cottenet J., Iacobelli S. et al. Epidemiology of endometriosis in France: a large, nation-wide study based on hospital discharge data. Biomed. Res. Int. 2016; 2016: 3260952. DOI: 10.1155/2016/3260952
  7. Eisenberg V.H., Weil C., Chodick G. et al. Epidemiology of endometriosis: a large population-based database study from a healthcare provider with 2 million members. BJOG. 2018; 125(1): 55–62. DOI: 10.1111/1471-0528.14711
  8. Morassutto C., Monasta L., Ricci G. et al. Incidence and estimated prevalence of endometriosis and adenomyosis in Northeast Italy: a data linkage study. PLoS One. 2016; 11(4): e0154227. DOI: 10.1371/journal.pone.0154227
  9. Ahn S.H., Monsanto S.P., Miller C. et al. Pathophysiology and immune dysfunction in endometriosis. Biomed. Res. Int. 2015; 2015: 795976. DOI: 10.1155/2015/795976
  10. Anglesio M.S., Papadopoulos N., Ayhan A. et al. Cancer-associated mutations in endometriosis without cancer. N. Engl. J. Med. 2017; 376(19): 1835–48. DOI: 10.1056/NEJMoa1614814
  11. Rahmioglu N., Nyholt D.R., Morris A.P. et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum. Reprod. Update. 2014; 20(5): 702–16. DOI: 10.1093/humupd/dmu015
  12. Kobayashi H., Higashiura Y., Shigetomi H. et al. Pathogenesis of endometriosis: the role of initial infection and subsequent sterile inflammation (review). Mol. Med. Rep. 2014; 9(1): 9–15. DOI: 10.3892/mmr.2013.1755
  13. Laschke M.W., Menger M.D. The gut microbiota: a puppet master in the pathogenesis of endometriosis? Am. J. Obstet. Gynecol. 2016; 215(1): 68.e1–4. DOI: 10.1016/j.ajog.2016.02.036
  14. Flores R., Shi J., Fuhrman B. et al. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. J. Transl. Med. 2012; 10: 253. DOI: 10.1186/1479-5876-10-253
  15. Gunjur A. Cancer and the microbiome. Lancet. Oncol. 2020; 21(7): 888. DOI: 10.1016/S1470-2045(20)30351-X
  16. Ata B., Yildiz S., Turkgeldi E. et al. The endobiota study: comparison of vaginal, cervical and gut microbiota between women with stage 3/4 endometriosis and healthy controls. Sci. Rep. 2019; 9(1): 2204. DOI: 10.1038/s41598-019-39700-6
  17. Mendling W., Palmeira-de-Oliveira A., Biber S. et al. An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review. Arch. Gynecol. Obstet. 2019; 300(1): 1–6. DOI: 10.1007/s00404-019-05142-8
  18. Walther-António M.R., Chen J., Multinu F. et al. Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med. 2016; 8(1): 122. DOI: 10.1186/s13073-016-0368-y
  19. Mariano A., Salzo A., Felice V. et al. Atopobium vaginae: a literature review, on findings and potential clinical implications. Muicrobiologia Medica. 2019; 34(1): 12–15. DOI: 10.4081/mm.2019.8014
  20. Lin W.-C., Chang C.Y.-Y., Hsu Y.-A. et al. Increased risk of endometriosis in patients with lower genital tract infection: a nationwide cohort study. Medicine (Baltimore). 2016; 95(10): e2773. DOI: 10.1097/MD.0000000000002773
  21. Campos G.B., Marques L.M., Rezende I.S. et al. Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. Fertil. Steril. 2018; 109(3): 549–60.e4. DOI: 10.1016/j.fertnstert.2017.11.009
  22. Skripnichenko Yu.P., Baranov I.I., Tokova Z.Z. Statistics of the preterm births. Russian Journal of Human Reproduction. 2014; 4: 11–14. (in Russian)
  23. Shiozaki A., Yoneda S., Yoneda N. et al. Intestinal microbiota is different in women with preterm birth: results from terminal restriction fragment length polymorphism analysis. PLoS One. 2014; 9(11): e111374. DOI: 10.1371/journal.pone.0111374
  24. Shiozaki A., Yoneda S., Nakabayashi M. et al. Multiple pregnancy, short cervix, part-time worker, steroid use, low educational level and male fetus are risk factors for preterm birth in Japan: a multicenter, prospective study. J. Obstet. Gynaecol. Res. 2014; 40(1): 53–61. DOI: 10.1111/jog.12120
  25. Kamga Y.M., Ngunde J.P., Akoachere J.-F.K.T. Prevalence of bacterial vaginosis and associated risk factors in pregnant women receiving antenatal care at the Kumba Health District (KHD), Cameroon. BMC Pregnancy Childbirth. 2019; 19(1): 166. DOI: 10.1186/s12884-019-2312-9
  26. Koren O., Goodrich J.K., Cullender T.C. et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell. 2012; 150(3): 470–80. DOI: 10.1016/j.cell.2012.07.008
  27. Madianos P.N., Bobetsis Y.A., Offenbacher S. Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms. J. Periodontol. 2013; 84(4 suppl.): S170–80. DOI: 10.1902/jop.2013.1340015
  28. Round J.L., Mazmanian S.K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl. Acad. Sci. USA. 2010; 107(27): 12204–9. DOI: 10.1073/pnas.0909122107
  29. Mei C., Yang W., Wei X. et al. The unique microbiome and innate immunity during pregnancy. Front. Immunol. 2019; 10: 2886. DOI: 10.3389/fimmu.2019.02886
  30. Gomez-Lopez N., Laresgoiti-Servitje E. T regulatory cells: regulating both term and preterm labor? Immunol. Cell Biol. 2012; 90(10): 919–20. DOI: 10.1038/icb.2012.48
  31. Faas M.M., Liu Y., Borghuis T. et al. Microbiota induced changes in the immune response in pregnant mice. Front Immunol. 2020; 10: 2976. Microbiota induced changes in the immune response in pregnant mice
  32. Baldassarre M.E., Palladino V., Amoruso A. et al. Rationale of probiotic supplementation during pregnancy and neonatal period. Nutrients. 2018; 10(11): 1693. DOI: 10.3390/nu10111693
  33. Browne P.D., Bolte A., Claassen E. et al. Probiotics in pregnancy: protocol of a double-blind randomized controlled pilot trial for pregnant women with depression and anxiety (PIP pilot trial). Trials. 2019; 20(1): 440. DOI: 10.1186/s13063-019-3389-1
  34. Kungurtseva E.A., Leshchenko O.Ya., Danusevich I.N. et al. Vaginal microecology in women with the non-specific genital inflammatory diseases and reproductive function disorders. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2013; 2(2): 197–201. (in Russian)
  35. Popkova S.M., Rakova E.B., Khramova E.E. et al. Microecological combinations of vaginal and intestinal biotopes in women with lower female reproductive tract inflammantory diseases and in adolescents girls with ovarian dysfunction. The Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2013; 33(4): 77–83. (in Russian)
  36. Kungurtseva E.A., Popkova S.M., Leshchenko O.Ya. Reciprocal formation of mucosal microflora of open cavities of different habitats in women as an important factor of their reproductive health. Annals of the Russian Academy of Medical Sciences. 2014; 69(9–10): 27–32. (in Russian)
  37. Shatalov A.E., Kupina A.D., Petrov Yu.A. Sterility of women as a consequence of inflammatory diseases of the genitals. International Journal of Applied and Fundamental Research. 2020; 2: 74–7. (in Russian)
  38. Petrov Yu.A. Family health is the health of the nation. M.; 2020. 312 p. (in Russian)

News

30 June 00:00
A New Issue of Doctor.Ru Neurology Psychiatry, Vol. 20, No. 5 (2021), Published

Find original articles and reviews covering various aspects of neurology, psychiatry and the interview with Professor Marina Arkadievna Kinkulkina

28 June 00:00
A New Issue of Doctor.Ru Internal Medicine, Vol. 20, No. 4 (2021), Published

Find original articles and reviews covering various aspects of cardiology, gastroenterology, internal medicine and the interview with Professor Elena Zelikovna Golukhova

 

3 May 17:06
A New Issue of Doctor.Ru Pediatrics, Vol. 20, No. 3 (2021), Published

Find original articles and reviews covering various aspects of pediatrics and the interview with Professor Evgeny Grigorievich Furman

3 May 17:06
A New Issue of Doctor.Ru Endocrinology, Vol. 20, No. 2 (2021), Published

Find original articles and reviews covering various aspects of endocrinology and the interview with Professor Valentin Viktorovich Fadeev

16 April 11:57
Igor Evgenievich Khatkov joined the American Surgical Association

Igor Evgenievich Khatkov, Head of A. S. Loginov Moscow Clinical Scientific and Practical Centre, Chief Oncologist in and for Moscow is now an honoured member of the American Surgical Association.

All news