Mechanisms of Insulin Resistance Formation in Polycystic Ovarian Disease and Therapeutic Effects from Myo Inositol

For citation: Chernukha G.E., Udovichenko M.A., Naydukova A.A. Mechanisms of Insulin Resistance Formation in Polycystic Ovarian Disease and Therapeutic Effects from Myo Inositol. Doctor.Ru. 2019; 11(166): 55–60. DOI: 10.31550/1727-2378-2019-166-11-55-60
01 october 2019

Objective of the Review: to perform a systematic analysis of data from contemporary sources regarding the mechanisms of insulin resistance (IR) formation in polycystic ovarian disease (PCOD) and regarding efficiency of hormone-free therapy for correction of metabolic and reproductive disorders in this group of patients.

Key Points: PCOD is the most common endocrine pathology in women of reproductive age. Patients with PCOD are at high risk of metabolic disorders, such as IR, hyperinsulinemia, disturbed glucose tolerance, type 2 diabetes mellitus, obesity, dislipidemy, hypertension.

Together with hormone-containing drugs in PCOD, drugs increasing sensitivity to insulin, reducing insulin and androgens secretion are used in correction of reproductive disorders. The analysis of literary sources showed that IR in PCOD patients is very often associated with myo inositol (MI) deficiency.

Conclusion: use of MI in PCOD patients improves metabolic and hormone profile, regulates menstrual period, reduces the risk of gestational diabetes mellitus, and improves extracorporal fertilization outcomes. Use of MI is an alternative therapy of metabolic disorders and ovulatory dysfunction in PCOD.

G.E. Chernukha — V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine of the Ministry of Health of Russia; 4 Academician Oparin St., Moscow, Russian Federation 117997. eLIBRARY.RU SPIN: 5514-3483. ORCID: http://orcid.org/0000-0002-9065-5689. E-mail: c-galina1@yandex.ru

M.A. Udovichenko — V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine of the Ministry of Health of Russia; 4 Academician Oparin St., Moscow, Russian Federation 117997. E-mail: mariia911@yahoo.com

A.A. Naydukova — V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine of the Ministry of Health of Russia; 4 Academician Oparin St., Moscow, Russian Federation 117997. E-mail: aleeshka@mail.ru

Contribution: Chernukha G.E. — patient management, study design, eview of critically important material, approval of the final article version; Udovichenko M.A. — a set of clinical material, manuscript text preparation, hematic publications reviewing; Naydukova A.A. — a set of clinical material, data processing analysis and interpretation, hematic publications reviewing.

The authors declare that they do not have any conflict of interests.

1 October 15:08
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