Menopausal Hormonotherapy and Venous Thromboembolic Events: Is There Any Correlation?

For citation: Kuznetsov M.R., Papysheva O.V. Menopausal Hormonotherapy and Venous Thromboembolic Events: Is There Any Correlation? Doctor.Ru. 2019; 11(166): 68–73. DOI: 10.31550/1727-2378-2019-166-11-68-73
1 October 15:46

Objective of the Review: to discuss the available data concerning the correlation between sex hormone administration, including menopausal hormonotherapy (MHT), and venous thromboembolic events (VTEE).
Key Points: the role of estrogens and gestagens in possible venous thrombosis is discussed. The data from a large-scale observational study are presented; the study enrolled 80,396 women aged 40 to 79 years old registered in GP databases of the United Kingdom and treated with various MHT from 1997 to 2017. It is demonstrated that, as far as VTEE is concerned, the safety of a combination of estradiol and didrogesteronis not significantly different from transdermal administration, however it is 4-5 times more efficient in prevention of cardiovascular disorders (arterial hypertension, diabetes mellitus, and atherosclerotic vascular disease). Also, a combination of estradiol and didrogesteron was associated with a minimal risk of venous thrombosis, irrespective of the mode of administration (cyclic or continuous), age, and body mass index of patients. Ultra-low doses of these medications demonstrated lower risk of thrombotic complications vs. controls.
Conclusion: the correct choice of MHT can contribute to its wider use, allowing to maximally reduce the risk of severe cardiovascular events with minimal risks of VTEE.

M.R. Kuznetsov — N.I. Pirogov Russian National Research Medical University; N.E. Bauman Municipal Clinical Hospital No.29; 1 Ostrovityanov Str., Moscow, Russian Federation 117997. eLIBRARY.RU SPIN: 7146-1348. E-mail: mrkuznetsov@mail.ru

O.V. Papysheva — N.E. Bauman Municipal Clinical Hospital No.29; 2 Gospitalnaya pl., Moscow, Russian Federation 111020. E-mail: viulen@mail.ru

Contribution: Kuznetsov M.R. — thematic publications reviewing, eview of critically important intellectual material; Papysheva O.V. — thematic publications reviewing, data analysis and interpretation.

The authors declare that they do not have any conflict of interests.

1 October 15:46
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