Menopausal Hormonal Therapy During COVID-19 Pandemic
Objective of the Review: To discuss the practicality and safety of menopausal hormonal therapy (MHT) during COVID-19 pandemic.
Key Points. Currently the age-related aspects of women’s health are given close attention. We have a clear idea of the physiological features of menopause and possible consequences of oestrogen deficit. No doubt that menopausal hormonal therapy (MHT) has protective effect regarding age-associated diseases. Still, COVID-19 pandemic caused by SARS-CoV-2 raises a lot of questions about the practicality of MHT initiation and prolongation. The article compares pathogenic mechanisms of coronavirus infection development with MHT effects; also, it describes the solution proposed by the leading international menopausal associations regarding MHT feasibility during pandemic and limited consultation possibilities.
Conclusion. Pathogenic features of the impact from SARS-CoV-2 and specific MHT effects for the haemostasis require thorough assessment of risks associated with MHT continuation. However it is worth noting that oestrogens are a key player in immune response and have multifaceted protective action for vascular endothelium. MHT is based on many years of clinical trials. Therefore, experts are of the opinion that MHT should be prescribed with account to potential complications caused by the coronavirus infection.
Contributions: Yakushevskaya, O.V. and Yureneva, S.V. — developed the concept of the article, collected information, and participated in composing the article, approved the final version submitted for publication.
Conflict of interest: The authors declare that they do not have any conflict of interests.
O.V. Yakushevskaya (Corresponding author) — V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynecology and Perinatal Medicine of the Ministry of Health of the Russian Federation; 4 Academician Oparin Str., Moscow, Russian Federation 117997. https://orcid.org/0002-7430-1207. E-mail: firstname.lastname@example.org
S.V. Yureneva — V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynecology and Perinatal Medicine of the Ministry of Health of the Russian Federation; 4 Academician Oparin Str., Moscow, Russian Federation 117997. https://orcid.org/0000-0003-2864-066X. E-mail: email@example.com
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