A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Dyslipoproteinemia and Plasma Levels of Proinflammatory Cytokines and C-Reactive Protein in Young Asthma Patients

DOI:10.31550/1727-2378-2018-152-8-45-49
For citation: Sobko E.A., Demko I.V., Kazmerchuk O.V., Abramov Yu.I., Kraposhina A.Yu., Egorov S.A., Soloviova I.A. Dyslipoproteinemia and Plasma Levels of Proinflammatory Cytokines and C-Reactive Protein in Young Asthma Patients. Doctor.Ru. 2018; 8(152): 45–49. DOI: 10.31550/1727-2378-2018-152-8-45-49
25 October 16:01

Study Objective: To evaluate the levels of lipid fractions, proinflammatory cytokines, and C-reactive protein (CRP) in peripheral blood in young asthma patients, for the purpose of identifying potential associations between these parameters.

Study Design: This was an open-label, prospective, non-randomized, comparative, clinical study.

Materials and Methods: One hundred and forty-nine people were examined: 123 asthma patients and 26 apparently healthy volunteers, including 13 men and 13 women with a median age of 33 [30; 35]. The asthma patients were divided into three groups, according to the severity of their asthma. Group I was made up of 29 patients with mild asthma (median age 22 [20; 25]); Group II was comprised of 64 patients with moderate asthma (median age 31 [24; 37]); and Group III had 30 patients with severe asthma (median age 39 [28; 43]). All participants were assessed for bronchial airflow and pulmonary function, as well as triglyceride, high-density lipoprotein, low-density lipoprotein, cholesterol, tumor necrosis factor (TNF)-α, interleukin 6 (IL-6), and CRP levels. The asthma patients also underwent the asthma control test (ACT).

Study Results: The ACT showed that in Group I complete or partial control of asthma was achieved, in 24.2% and 75.8% of the patients, respectively. In Group II complete or partial control of asthma was achieved, in 25% and 42.2% of the patients, respectively, but in 32.8% their asthma remained uncontrolled. Most of the patients with severe asthma (80.0%) continued to have uncontrolled disease. Patients with moderate-to-severe and severe asthma had higher TNF-α and IL-6 levels in peripheral blood plasma than did patients with mild asthma.

Correlation analysis revealed an association between clinical and functional parameters, on the one hand, and proinflammatory cytokine and CRP levels, on the other, in patients with severe asthma; and between proinflammatory cytokine, CRP, and lipoprotein levels in patients with moderate-to-severe and severe asthma. The highest levels of triglycerides were seen in patients with severe asthma, compared with patients with mild and moderate-to-severe asthma (р<0.05).

Conclusion: The study showed that even young asthma patients have systemic inflammation, which worsens with the severity of the disease and is present between asthma exacerbations. Increased IL-6, TNF-α, and CRP levels may act as trigger factors, influencing the activation of lipid metabolism and a consequent increase in cardiovascular risk.

E.A. Sobko — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. Territorial Clinical Hospital, Krasnoyarsk. E-mail: sobko29@mail.ru

I.V. Demko — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. Territorial Clinical Hospital, Krasnoyarsk. E-mail: demko64@mail.ru

O.V. Kazmerchuk — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. E-mail: olguna24@mail.ru

Yu.I. Abramov — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. E-mail: yuriyab1997@gmail.com

A.Yu. Kraposhina — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. Territorial Clinical Hospital, Krasnoyarsk. E-mail: angelina-maria@inbox.ru

S.A. Egorov — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. Territorial Clinical Hospital, Krasnoyarsk. E-mail: dlyavsego89@mail.ru

I.A. Soloviova — V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health. Territorial Clinical Hospital, Krasnoyarsk. E-mail: solovieva.irina@inbox.ru

Доктор.ру
25 October 16:01
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