ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Fibroid Heart Markers in Patients with Atrial Fibrillation

DOI:10.31550/1727-2378-2020-19-5-14-18
Bibliography link: Moseychuk K.A., Sinyaeva A.S., Filippov E.V. Fibroid Heart Markers in Patients with Atrial Fibrillation. Doctor.Ru. 2020; 19(5): 14–18. (in Russian) DOI: 10.31550/1727-2378-2020-19-5-14-18
22 July 17:27

Objective of the Review: to sum up contemporary references on the use of some serum myocardial fibrosis markers in clinical practice in patients with atrial fibrillation (AF) as potential prognostic AF outcome predictors, recurrent seizures and antiarrhythmic therapy efficiency.

Key Points. The article contains a review of references in the use of such biomarkers as galectin 3, fibronectin and tissue growth factor β1 (TGF-β1) in non-invasive diagnosis of myocardial fibrosis in AF patients. Pre-clinical information indicates that galectin 3 is of great significance for myocardial fibrogenesis in experimental models. There is a correlation between galectin 3 serum levels in AF patients and marked left atrium fibrosis (r = 0.696, p < 0.001). It is noted that in patients with AF, galectin 3 levels are 3 times higher than in general population.

TGF-β1 is likely to play the most important role in pathological fibrosis. High plasma concentration of TGF-β1 is a potential non-invasive predictor of electroanatomic remodelling of left atrium in nonvalvular AF. There is a positive correlation between serum TGF-β1 and left atrium fibrosis rate in Af patients. Serum TGF-β1 concentration was significantly higher in patients with recurrent AF vs. patients without relapses, and is an independent risk factor of relapse.

Up to date there is only sparse information on the relationship between serum fibronectin and risk of AF. Data are available that fibronectin level was statistically higher in patients with paroxysmal AF vs. healthy subjects. Besides it was found out that fibronectin level is a predictor of electric remodelling in left atrium myocardium. No researches confirming that fibronectin concentration correlates with the rate of myocardial fibrosis are described in modern references.

Conclusion. Up to date, measurement of galectin 3, fibronectin and TGF-β1 to diagnose myocardial fibrosis has been studied mostly in experimental trials. Use of these markers in clinical practice is described in small samples.

Contributions: Moseychuk, K.A. and Sinyaeva, A.S. — thematic publications reviewing; Filippov, E.V. — review of critically important material, approval of the manuscript for publication.

Conflict of interest: The authors declare that they do not have any conflict of interests.

K.A. Moseychuk (Corresponding author) — Ryazan State Medical University of the Ministry of Health of the Russian Federation; 9 Vysokovoltnaya Str., Ryazan, Russian Federation 390026. eLIBRARY.RU SPIN: 1297-9721. E-mail: ka.moseychuk@gmail.com

A.S. Sinyaeva — Ryazan State Medical University of the Ministry of Health of the Russian Federation; 9 Vysokovoltnaya Str., Ryazan, Russian Federation 390026. E-mail: ka.moseychuk@gmail.com

E.V. Filippov — Ryazan State Medical University of the Ministry of Health of the Russian Federation; 9 Vysokovoltnaya Str., Ryazan, Russian Federation 390026. eLIBRARY.RU SPIN: 2809-2781. E-mail: dr.philippov@gmail.com

Доктор.ру

Received: 20.12.2019
Accepted: 31.03.2020

22 July 17:27
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