ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Central Hemodynamic Parameters in Patients with Hypertension, Including in Metabolic Syndrome or with Subclinical Hypothyroidism

Bibliography link: Andreeva L. A., Panchenkova L. A., Martynov A. I., Troshina E. A., Khamidova Kh. A., Yurkova T. E. Central Hemodynamic Parameters in Patients with Hypertension, Including in Metabolic Syndrome or with Subclinical Hypothyroidism. Doctor.Ru. 2018; 4(148): 48–52.
10 July 16:55

Study Objective: To analyze 24-hour central aortic blood pressure (CABP) and arterial stiffness profiles in hypertensive patients, including those with metabolic syndrome or subclinical hypothyroidism (sHT).

Study Design: This was a one-stage, cross-sectional study.

Materials and Methods: Eighty-eight patients were examined in the following three groups: patients with hypertension (n = 32), patients with hypertension as a component of metabolic syndrome (n = 34), and patients with hypertension and sHT (n = 22). The control group was made up of 22 age- and sex-matched apparently healthy people. All subjects underwent 24-hour blood pressure monitoring and an assessment of CABP and arterial stiffness.

Study Results: CABP did not differ significantly among the three groups of hypertensive patients, all of whom were receiving antihypertensive treatment. There was, however, a trend toward increased CABP in comorbid patients. In patients with hypertension alone, pulse pressure amplification and pulse wave velocity (PWV) were lower to a statistically significant degree than in hypertensive patients with metabolic syndrome. The aortic augmentation index was significantly higher in hypertensive patients with and without sHT than in those with hypertension and metabolic syndrome. The pulse time index of norm for PWV values was significantly higher in patients who had hypertension alone, than in those whose hypertension was associated with metabolic syndrome or who had hypertension and sHT.

Statistically significant correlations were found between the pulse time index of norm for PWV values and left-ventricular mass (r = –0.37), waist circumference (r = –0.50), triglyceride levels (r = –0.31), and pulse pressure amplification (r = –0.28).

Conclusion: Comorbid patients showed the greatest loss in elasticity of major arteries and had a more pronounced left ventricular burden.

L. A. Andreeva — Outpatient Clinic No. 1, Administrative Department of the President of the Russian Federation, Moscow. A. I. Yevdokimov Moscow State University of Medicine and Dentistry. E-mail: arfelia_marnessa@mail.ru

L. A. Panchenkova — A. I. Yevdokimov Moscow State University of Medicine and Dentistry. E-mail: lapanchenkova@mail.ru

A. I. Martynov — A. I. Yevdokimov Moscow State University of Medicine and Dentistry. Medical Science and Teaching Center, Administrative Department of the President of the Russian Federation, Moscow. E-mail: anatmartynov@mail.ru

E. A. Troshina — National Medical Research Center for Endocrinology, Moscow. E-mail: e.a.troshina@mail.ru

Kh. A. Khamidova — A. I. Yevdokimov Moscow State University of Medicine and Dentistry. E-mail: k.khamidova@mail.ru

T. E. Yurkova — A. I. Yevdokimov Moscow State University of Medicine and Dentistry. E-mail: dr_tata@km.ru

Доктор.ру
10 July 16:55
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