A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Cardio-Ankle Vascular Index in Patients with Hypertension

For citation: A. N. Sumin, A. V. Shcheglova, N. V. Fyodorova, G. V. Artamonova. Cardio-Ankle Vascular Index in Patients with Hypertension // Doctor.Ru. 2016; №11(128): 28–32.
13 December 00:00

Study Objective: To evaluate the frequency of detecting abnormal cardio-ankle vascular index (CAVI) values in patients with hypertension and factors associated with these abnormal values, based on the results of the ESSE-RF (Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation) study obtained in Kemerovo Region.

Materials and Methods: The study was performed in a random sample of 2,000 males and females, aged 25 to 64. The percentage of subjects who agreed to participate in the study was 81.4% (1,628 subjects). Overall, 1,595 (98%) of patients had volume sphygmography accompanied by automatic measurement of CAVI. A total of 709 patients with hypertension (blood pressure [BP] ≥ 140/90 mm Hg or < 140/90 mm Hg in those receiving antihypertensive therapy) were divided into two groups, depending on their CAVI values: in Group 1 (n = 124) CAVI was ≥ 9.0, in Group 2 (n = 585) it was < 9.0.

Study Results: Higher CAVI values were associated with a more advanced age (р < 0.001). Patients with CAVI ≥9.0 had significantly higher blood levels of creatinine (р = 0.019) and uric acid (р = 0.024) than those whose CAVI was < 9.0. In Group 1, BP was significantly higher than in Group 2: systolic BP 153.0 (143.5; 167.8) mm Hg vs. 145.5 (134.0; 156.0) mm Hg and diastolic BP 95.8 (88.8; 105.8) mm Hg vs. 92.0 (84.0; 100.0) mm Hg (р < 0.001 for both comparisons). A multivariate analysis identified the following two strong independent predictors of high CAVI: age (odds ratio [OR] 1.08; 95% confidence interval [CI]: 1.05–1.10; р <0.001) and blood creatinine levels (OR 1.02; 95% CI: 1.0–1.03; р = 0.0021).

Conclusion: Overall, 17.5% of patients with hypertension had abnormal CAVI values. Independent factors associated with these abnormal values were the patient's age and blood creatinine level. In patients with hypertension, evaluation of CAVI helps identify patients at higher risk of cardiovascular complications and assess the efficacy of medication treatment. It is also useful in risk factor management as part of preventive strategies.

A. N. Sumin — Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. E-mail: sumian@cardio.kem.ru

A. V. Shcheglova — Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. E-mail: nura.karpovitch@yandex.ru

N. V. Fyodorova — Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. E-mail: fedonv@cardio.kem.ru

G. V. Artamonova — Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. E-mail: artamonova@kemcardio.ru


Доктор.ру
13 December 00:00
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