The Influence of Empagliflozin on Vascular Age and Key Cardiovascular Risk Factors in Type 2 Diabetes Mellitus Patients

For citation: Nedogoda S.V., Palashkin R.V., Barykina I.N., Salasyuk A.S., Chumachek E.V., Smirnova V.O., Popova E.A. The Influence of Empagliflozin on Vascular Age and Key Cardiovascular Risk Factors in Type 2 Diabetes Mellitus Patients. Doctor.Ru. 2018; 8(152): 6–11. DOI: 10.31550/1727-2378-2018-152-8-6-11
25 october 2018

Study Objective: To assess the potential angioprotective effects of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in type 2 diabetes mellitus (T2DM) patients previously treated with metformin only.

Study Design: This was an open-label study.

Materials and Methods: Fifty patients with metabolic syndrome and T2DM took part in a 24-week study. The effects of empagliflozin on vascular stiffness, central hemodynamics, laboratory parameters, and vascular age, calculated using the SCORE scale, were assessed in these patients.

Study Results: After the treatment regimen was fortified with empagliflozin, the target glycated hemoglobin (HbA1c) level was achieved in 88% of the patients. A number of parameters were reduced, including anthropometric measurements (body weight by 3.65%, waist circumference by 1.93%, body mass index by 3.8%; p < 0.05 for all parameters) and laboratory markers of vascular ageing (HbA1c by 10.13%, total cholesterol by 8%, low-density lipoprotein cholesterol by 7.6%, leptin by 17.8%, Homeostatic Model Assessment for Insulin Resistance by 24.13%, and high-sensitivity C-reactive protein by 34.77%; p < 0.05 for all parameters). There was a significant reduction in the parameters of vascular stiffness (carotid-femoral pulse wave velocity by 8.88%) and central hemodynamics (augmentation index by 6.55% and central pulse pressure by 7.8%). Empagliflozin, however, does not significantly change vascular age calculated using the SCORE scale, because glucose metabolism parameters and T2DM status are not used in this scale, which is one of its major limitations.

Conclusion: In T2DM patients who have not achieved target HbA1c levels, empagliflozin as an additional therapy improves HbA1c levels and provides good angioprotection.

S.V. Nedogoda — Volgograd State Medical University, Russian Ministry of Health. E-mail: nedogodasv@rambler.ru

R.V. Palashkin — Volgograd State Medical University, Russian Ministry of Health. E-mail: oldgodlor@yandex.ru

I.N. Barykina — Volgograd State Medical University, Russian Ministry of Health. E-mail: irinbarykin@yandex.ru

A.S. Salasyuk — Volgograd State Medical University, Russian Ministry of Health. E-mail: solarheart7@gmail.com

E.V. Chumachek — Volgograd State Medical University, Russian Ministry of Health. E-mail: elena-chumachek@yandex.ru

V.O. Smirnova — Volgograd State Medical University, Russian Ministry of Health. E-mail: 3asabird@inbox.ru

E.A. Popova — Volgograd State Medical University, Russian Ministry of Health. E-mail: cutting_saw@mail.ru

25 October 09:42
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