Outcomes of Epilepsy Surgery

Bibliography link: Areshkina I.G., Sapronova M.R., Schnaider N.A., Narodova E.A., Dmitrenko D.V. Outcomes of Epilepsy Surgery. Doctor.Ru. 2020; 19(4): 29–34. (in Russian) DOI: 10.31550/1727-2378-2020-19-4-29-34
13 July 12:44

Objective of the Review: To analyze outcomes of epilepsy surgery, factors predicting the achievement of long-term remission in the postoperative period, and responses to the withdrawal and adjustment of anti-epileptic treatment in patients who have undergone surgery.

Key Points: Prognostic factors of favorable outcomes of epilepsy surgery are related to structural abnormalities of the brain identified by magnetic resonance imaging (MRI), consistency between pre-operative MRI findings and electroencephalographic monitoring data, and the possibility of completely removing the epileptogenic zone. Surgical therapy is recognized as a valuable option for patients, including children, with drug-resistant epilepsy.

Conclusion: More than 50% of epilepsy patients who undergo surgery achieve seizure remission thereafter, making it possible to reduce the dosage of anti-epileptic drugs (AED) or discontinue them all together. The average time until the start of AED tapering after epilepsy surgery is one to two years, and the average period until discontinuation of AED is three years. The decision to discontinue medication treatment should be personalized.

Contributions: Areshkina, I.G. — selected relevant materials; analyzed and interpreted data; wrote the manuscript; Sapronova, M.R. and Narodova, E.A. — selected relevant materials; analyzed and interpreted data; Schnaider, N.A. and Dmitrenko, D.V. — checked crucial content; approved the final version of the manuscript submitted for publication.

Conflict of interest: The authors declare that they do not have any conflict of interests.

I.G. Areshkina (Corresponding author) — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. E-mail:

M.R. Sapronova — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. Е-mail:

N.A. Schnaider — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology (a Federal Government-funded Institution), Russian Federation Ministry of Health; 3 Bekhterev St., St. Petersburg, Russian Federation 192019. eLIBRARY.RU SPIN: 6517-0279. Е-mail:

E.A. Narodova — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. eLIBRARY.RU SPIN: 9353-6628. Е-mail:

D.V. Dmitrenko — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. eLIBRARY.RU SPIN: 9180-6623. Е-mail:


Received: 29.03.2020
Accepted: 07.04.2020

13 July 12:44
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