A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Localized Chondroprotective Therapy as a Part of Comprehensive Treatment for Chronic Back Pain

DOI:10.31550/1727-2378-2019-161-6-27-30
For citation: Antipenko E.A., Erokhina M.N., Sedyshev D.V., Kozlova T.Yu., Lapshina O.V. Localized Chondroprotective Therapy as a Part of Comprehensive Treatment for Chronic Back Pain. Doctor.Ru. 2019; 6(161): 27–30. DOI: 10.31550/1727-2378-2019-161-6-27-30
10 June 07:43

Study Objective: To evaluate the efficacy of injections of chondroitin sulfate (Mucosate) as localized therapy in patients receiving comprehensive treatment for chronic back pain.

Study Design: This was an open-label comparative prospective study.

Materials and Methods: Forty-five patients with chronic nonspecific low-back pain received treatment, including antidepressants, anticonvulsants, physical therapy, and 1% lidocaine nerve block every other day (a total of five procedures). In the main group (n = 30), Mucosate 2 ml was additionally administered intramuscularly into para-articular and paravertebral tissues surrounding the facet joints, followed by ten intramuscular injections of Mucosate. The following parameters were assessed: changes in pain intensity, degree of limitation of motion, and parameters of the Chronic Pain Grade Scale (CPGS), after 12 and 30 days.

Study Results: On day 12, pain intensity was reduced by 3.2 points in the main group and by 1.5 points in the comparison group (р = 0.02). On day 30, 50% or greater reduction in pain intensity was reported in 18 (60.0%) patients in the main group and in four (26.7%) patients in the comparison group (р = 0.03).

Conclusion: Comprehensive localized treatment with a local anesthetic and the chondroprotective agent Mucosate is an appropriate approach, affecting various pathological components of the chronic pain syndrome.

E.A. Antipenko — Volga District Medical Research University, Russian Ministry of Health; 10/1 Minin Square, Nizhny Novgorod, Russian Federation 603005. eLIBRARY.RU SPIN: 7708-9068. ORCID: 0000-0002-8972-9150. E-mail: antipenkoea@gmail.com

M.N. Erokhina — Volga District Medical Research University, Russian Ministry of Health; 10/1 Minin Square, Nizhny Novgorod, Russian Federation 603005. eLIBRARY.RU SPIN: 3265-2899. E-mail: mne_001@mail.ru

D.V. Sedyshev — N.A. Semashko Nizhny Novgorod Regional Clinical Hospital; 190 Rodionov St., Nizhny Novgorod, Russian Federation 603126. E-mail: antipenkoea@gmail.com

T.Yu. Kozlova — N.A. Semashko Nizhny Novgorod Regional Clinical Hospital; 190 Rodionov St., Nizhny Novgorod, Russian Federation 603126. E-mail: antipenkoea@gmail.com

O.V. Lapshina — N.A. Semashko Nizhny Novgorod Regional Clinical Hospital; 190 Rodionov St., Nizhny Novgorod, Russian Federation 603126. eLIBRARY.RU SPIN: 6012-6193. E-mail: olga-med@list.ru


The authors declare that they do not have any conflict of interests.

 

Доктор.ру
10 June 07:43
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