The Role of Brain Hemispheric Specialization in Emotional Regulation

For citation: Narodova E.A., Schnaider N.A., Narodova V.V., Erakhtin E.E., Karnaukhov V.E., Dmitrenko D.V. The Role of Brain Hemispheric Specialization in Emotional Regulation. Doctor.Ru. 2020; 19(4): 23–28. (in Russian) DOI: 10.31550/1727-2378-2020-19-4-23-28
13 July 12:02

Objective of the Review: To describe brain lateralization of emotional regulation.

Key Points: The authors analyze a number of studies that focused on brain lateralization of emotional regulation and discuss prospects for making use of this phenomenon in clinical neurology. The analysis includes articles identified in a literature search in Russian (E-Library) and foreign (PubMed, Scopus, Oxford University Press, Springer, and Web of Science Core Collection) databases. Analysis of the available data suggests that the left hemisphere is more resistant to mood changes than the right hemisphere, while the latter may play an important role in immediate (more rapid) positive or negative emotional responses in patients with neurological disorders.

Conclusion: Despite great interest in this subject from Russian and foreign researchers, the available data are limited and fragmented. This is because the theoretical and methodological aspects of this subject need comprehensive research. Studies of the role of interhemispheric and intrahemispheric connections in the brain, including electroencephalogram markers such as interhemispheric and intrahemispheric coherence, are promising in that the results of these studies may be used in the clinical management of patients with anxiety disorders.

Contributions: Narodova, E.A. — reviewed relevant publications; participated in writing the manuscript and designing the composition of the article; Schnaider, N.A. — developed the concept of the article; selected publications for analysis; participated in writing the manuscript; Narodova, V.V. and Dmitrenko, D.V. — reviewed relevant publications; participated in designing the composition of the article; Erakhtin, E.E. and Karnaukhov, V.E. — reviewed relevant publications.

Conflict of interest: The authors declare that they do not have any conflict of interests.

E.A. Narodova (Corresponding author) — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. eLIBRARY.RU SPIN: 9353-6628. E-mail: katya_n2001@mail.ru

N.A. Schnaider — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology (a Federal Government-funded Institution), Russian Federation Ministry of Health; 3 Bekhterev St., St. Petersburg, Russian Federation 192019. eLIBRARY.RU SPIN: 6517-0279. Е-mail: naschnaider@yandex.ru

V.V. Narodova — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. eLIBRARY.RU SPIN: 1431-8530. E-mail: narodova_v@mail.ru

E.E. Erakhtin — N.S. Karpovich Krasnoyarsk Interregional Clinical Emergency Hospital (a Territorial Government-funded Healthcare Institution); 17 Kurchatov St., Krasnoyarsk, Russian Federation 660062. E-mail: eepn2009@mail.ru

V.E. Karnaukhov — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. E-mail: karnauhov.vlad@mail.ru

D.V. Dmitrenko — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. eLIBRARY.RU SPIN: 9180-6623. E-mail: mart2802@yandex.ru


Received: 29.11.2019
Accepted: 06.02.2020

13 July 12:02
  1. Brancucci A., Lucci G., Mazzatenta A., Tommasi L. Asymmetries of the human social brain in the visual, auditory and chemical modalities. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2009; 364(1519): 895–914. DOI: 10.1098/rstb.2008.0279
  2. Rogers L.J. Eye and ear preferences. In: Rogers L.J., Vallortigara G., eds. Lateralized brain functions. Methods in human and non-human species. New York: Humana Press; 2007: 79–102.
  3. Forrester G.S., Todd B.K. A comparative perspective on lateral biases and social behavior. In: Forrester G.S., Hopkins W.D., Hudry K., Lindell A., eds. Cerebral lateralization and cognition: evolutionary and developmental investigations of behavioral biases. Progress in brain research. Elsevier; 2018; 238: 377–403. DOI: 10.1016/bs.pbr.2018.06.014
  4. Quaresmini C., Forrester G.S., Spiezio C., Vallortigara G. Social environment elicits lateralized behaviors in gorillas and chimpanzees. J. Comp. Psychol. 2014; 128(3): 276–84. DOI: 10.1037/a0036355
  5. Boeving E.R., Belnap S.C., Nelson E.L. Embraces are lateralized in spider monkeys (Ateles fusciceps rufiventris). Am. J. Primatol. 2017; 79(6): e22654. DOI: 10.1002/ajp.22654
  6. Karenina K., Giljov A., De Silva S., Malashichev Y. Social lateralization in wild Asian elephants: visual preferences of young and mothers. Behav. Ecol. Sociobiol. 2018; 72: 21. DOI: 10.1007/s00265-018-2440-7
  7. Vallortigara G., Versace E. Laterality at the neural, cognitive, and behavioral levels. In: Call J., ed. APA handbook of comparative psychology: Basic concepts, methods, neural substrate, and behavior. Vol. 1. Washington: American Psychological Association; 2017: 557–77.
  8. Najt P., Bayer U., Hausmann M. Models of hemispheric specialization in facial emotion perception — a reevaluation. Emotion. 2013; 13(1): 159–67. DOI: 10.1037/a0029723
  9. Kelley N.J., Hortensius R., Schutter D.J., Harmon-Jones E. The relationship of approach/avoidance motivation and asymmetric frontal cortical activity: a review of studies manipulating frontal asymmetry. Int. J. Psychophysiol. 2017; 119: 19–30. DOI: 10.1016/j.ijpsycho.2017.03.001
  10. Davidson R.J. Cerebral asymmetry, emotion, and affective style. In: Davidson R.J., Hugdahl K., eds. Brain asymmetry. Cambridge, MA: The MIT Press; 1995: 361–87.
  11. Karenina K., Giljov A., Ingram J., Rowntree V.J., Malashichev Y. Lateralization of mother — infant interactions in a diverse range of mammal species. Nat. Ecol. Evol. 2017; 1(2): 30. DOI: 10.1038/s41559-016-0030
  12. Fusar-Poli P., Placentino A., Carletti F., Allen P., Landi P., Abbamonte M. et al. Laterality effect on emotional faces processing: ALE meta-analysis of evidence. Neurosci. Lett. 2009; 452(3): 262–67. DOI: 10.1016/j.neulet.2009.01.065
  13. Gainotti G. Unconscious processing of emotions and the right hemisphere. Neuropsychologia. 2012; 50(2): 205–18. DOI: 10.1016/j.neuropsychologia.2011.12.005
  14. Gainotti G. Emotional behavior and hemispheric side of the lesion. Cortex. 1972; 8(1): 41–55.
  15. Jansari A., Rodway P., Goncalves S. Identifying facial emotions: valence specific effects and an exploration of the effects of viewer gender. Brain Cogn. 2011; 76(3): 415–23. DOI: 10.1016/j.bandc.2011.03.009
  16. Poole B.D., Gable P.A. Affective motivational direction drives asymmetric frontal hemisphere activation. Exp. Brain Res. 2014; 232(7): 2121–30. DOI: 10.1007/s00221-014-3902-4
  17. Harmon-Jones E., Gable P.A., Peterson C.K. The role of asymmetric frontal cortical activity in emotion-related phenomena: a review and update. Biol. Psychol. 2010; 84(3): 451–62. DOI: 10.1016/j.biopsycho.2009.08.010
  18. Prete G., Capotosto P., Zappasodi F., Tommasi L. Contrasting hemispheric asymmetries for emotional processing from event-related potentials and behavioral responses. Biol. Psychol. 2010; 84(3): 451–62. DOI: 10.1016/j.biopsycho.2009.08.010
  19. Baijal S., Srinivasan N. Emotional and hemispheric asymmetries in shifts of attention: an ERP study. Cogn. Emot. 2011; 25(2): 280–94. DOI: 10.1080/02699931.2010.492719
  20. Pizzagalli D.A., Sherwood R.J., Henriques J.B., Davidson R.J. Frontal brain asymmetry and reward responsiveness a source-localization study. Psychol. Sci. 2005; 16(10): 805–13. DOI: 10.1111/j.1467-9280.2005.01618.x
  21. Barbas H. Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices. Brain Res. Bull. 2000; 52(5): 319–30. DOI: 10.1016/s0361-9230(99)00245-2
  22. Davidson R.J. What does the prefrontal cortex “do” in affect: perspectives on frontal EEG asymmetry research. Biol. Psychol. 2004; 67(1–2): 219–33. DOI: 10.1016/j.biopsycho.2004.03.008
  23. Ligeza T.S., Wyczesany M., Tymorek A.D., Kamiński M. Interactions between the prefrontal cortex and attentional systems during volitional affective regulation: an effective connectivity reappraisal study. Brain Topogr. 2016; 29(2): 253–61. DOI: 10.1007/s10548-015-0454-2
  24. Narumoto J., Okada T., Sadato N., Fukui K., Yonekura Y. Attention to emotion modulates fMRI activity in human right superior temporal sulcus. Brain Res. Cogn. Brain Res. 2001; 12(2): 225–31. DOI: 10.1016/s0926-6410(01)00053-2
  25. Sato W., Kochiyama T., Yoshikawa S., Naito E., Matsumura M. Enhanced neural activity in response to dynamic facial expressions of emotion: an fMRI study. Brain Res. Cogn. Brain Res. 2004; 20(1): 81–91. DOI: 10.1016/j.cogbrainres.2004.01.008
  26. Baas D., Aleman A., Kahn R.S. Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Res. Brain Res. Rev. 2004; 45(2): 96–103. DOI: 10.1016/j.brainresrev.2004.02.004
  27. Killgore W.D., Yurgelun-Todd D.A. The right-hemisphere and valence hypotheses: could they both be right (and sometimes left)? Soc. Cogn. Affect. Neurosci. 2007; 2(3): 240–50. DOI: 10.1093/scan/nsm020
  28. von Stein A., Sarnthein J. Different frequencies for different scales of cortical integration: from local gamma to long range alpha/theta synchronization. Int. J. Psychophysiol. 2000; 38(3): 301–13. DOI: 10.1016/S0167-8760(00)00172-0
  29. Güntekin B., Başar E. A review of brain oscillations in perception of faces and emotional pictures. Neuropsychologia. 2014; 58: 33–51. DOI: 10.1016/j.neuropsychologia.2014.03.014
  30. Jamal W., Das S., Maharatna K., Pan I., Kuyucu D. Brain connectivity analysis from EEG signals using stable phase-synchronized states during face perception tasks. Phys. A: Stat. Mech. Appl. 2015; 434: 273–95. DOI: 10.1016/j.physa.2015.03.087
  31. Ivanov L.B. The state of intra- and interhemispheric integration according to the coherent analysis of EEG in healthy children and pathology. In: Proceedings of the international conference “Clinical Neuroscience: Neurophysiology, Neurology, Neurosurgery”, V East European Conference “Epilepsy and Clinical Neurophysiology.” Yalta — Gurzuf, June 1–10, 2003. Gurzuf; 2003: 32–5. (in Russian)
  32. Vecchio F., Babiloni C., Buffo P., Rossini P.M., Bertini M. Inter-hemispherical functional coupling of EEG rhythms during the perception of facial emotional expressions. Clin. Neurophysiol. 2013; 124(2): 263–72. DOI: 10.1016/j.clinph.2012.03.083
  33. Tramo M.J., Shah G.D., Braida L.D. Functional role of auditory cortex in frequency processing and pitch perception. J. Neurophysiol. 2002; 87(1): 122–39. DOI: 10.1152/jn.00104.1999
  34. Ishizu T., Zeki S. Toward a brain-based theory of beauty. PLoS One. 2011; 6(7): e21852. DOI: 10.1371/journal.pone.0021852
  35. James W. The principles of psychology. New York: Henry Holt and Company; 1890. XVIII, 1393 p.
  36. Kaas J.H. Plasticity of sensory and motor maps in adult mammals. Annu. Rev. Neurosci. 1991; 14: 137–67. DOI: 10.1146/annurev.ne.14.030191.001033
  37. York G.K. The cerebral localization of creativity. In: Rose F.C., ed. Neurology of the arts: paintings, music, literature. London: Imperial College Press; 2004: 1–12.
  38. Kuzikova М.Е., Manicheva Yu.S., Shabaev V.S. The specifity of psychophysiological processes of people with different profiles of the cerebral asymmetry. Health is the cornerstone of human potential: challenges and ways forward. 2018; 13(1): 304–8. (in Russian)
  39. Partanen E., Kujala T., Tervaniemi M., Huotilainen M. Prenatal music exposure induces long-term neural effects. PLoS One. 2013; 8(10): e78946. DOI: 10.1371/journal.pone.0078946
  40. Schlaug G. Musicians and music making as a model for the study of brain plasticity. Prog. Brain Res. 2015; 217: 37–55. DOI: 10.1016/bs.pbr.2014.11.020
  41. Demarin V., Morovic S., Bene R. Neuroplasticity. Periodicum Biologorum. 2014; 116(2): 209–11.
  42. Kawabata H., Zeki S. The neural correlates of desire. PLoS One. 2008; 3(8): e3027. DOI: 10.1371/journal.pone.0003027
  43. Beitrag zum Wohlbefinden. Serotonin, Noradrenalin, Adrenalin, Dopamin und Beta-Endorphin als psychophysiologische Indikatoren. Diplomarbeit. Wien; 2004.
  44. Chernikova I.V. Thought in the aspect of transdisciplinary research. Bulletin of Siberian Medicine. 2014; 13(4): 149–55. (in Russian). DOI: 10.20538/1682-0363-2014-4-149-155
  45. Narodova E.A., Shnayder N.A., Prokopenko S.V., Narodova V.V., Narodov A.A., Dmitrenko D.V. Epidemiology of drug resistant epilepsy in adults. Bulletin of Siberian Medicine. 2018; 17(3): 207–16. (in Russian). DOI: 10.20538/1682-0363-2018-3-207-216
  46. Shipkova K.M. Brain organization of “the Theory of Mind”. Medical Psychology in Russia. 2018; 10(3): 5. (in Russian). DOI: 10.24411/2219-8245-2018-13050
  47. Pascal-Leone A., Amedi A., Fregni F., Merabet L.B. The plastic human brain cortex. Annu. Rev. Neurosci. 2005; 28: 377–401. DOI: 10.1146/annurev.neuro.27.070203.144216
  48. Carota A., Iaria G., Berney A., Bogousslavsky G. Understanding Van Gogh’s Night: bipolar disorder. In: Bogousslavsky J., Boller F., eds. Neurological disorders in famous artists. Front Neurol. Neurosci. Basel: Kargerl; 2005; 19: 121–31.
  49. Blanke O., Landis T. The metaphysical art of Giorgio de Chirico. Migraine or epilepsy? Eur. Neurol. 2003; 50: 191–4. DOI: 10.1159/000073858
  50. Bogousslavsky J. The neurology of art — the example of Giorgio de Chirico. Eur. Neurol. 2003; 50(4): 189–90. DOI: 10.1159/000073857
  51. Ivanitsky G.A. Individual stable patterns of human brain rhythms as a reflection of mental processes. Modern Technologies in Medicine. 2019; 11(1): 116–31. (in Russian). DOI: 10.17691/stm2019.11.1.14
  52. Headache causes, treatments, and types. URL: www.relieve-migraine-headache.com (accessed March 18, 2020).
  53. Ferrari M.D., Haan J. Migraine aura, illusory vertical splitting, and Picasso. Cephalalgia. 2000; 20(8): 686. DOI: 10.1111/j.1468-2982.2000.00113.x
  54. Haan J. Migraine and painting. Presented at: the International Headache Congress. Philadelphia; 2009.
  55. Leventhal H. Emotions: a basic problem for social psychology. In: Nemeth С., ed. Social psychology: classic and contemporary integrations. Chicago: Rand McNally; 1974: 1–51.
  56. Leventhal H. A perceptual-motor theory of emotion. In: Berkowitz L., ed. Advances in experimental social psychology. New York: Academic Press; 1984; 17: 117–82.
  57. Tushkova K.V., Bundalo N.L. Reactive and personal anxiety in men and women with post-traumatic stress disorder of varying severity. Siberian Medical Review. 2013; 3(81): 89–93. (in Russian)


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