A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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A Comparative Analysis of Olfactory Function in Healthy People and Patients with Parkinson’s Disease or Essential Tremor

DOI:10.31550/1727-2378-2019-161-6-12-17
For citation: Pokhabov D.D., Tunik M.E., Abramov V.G., Prokopenko S.V., Pokhabov D.V., Sadovsky M.G. A Comparative Analysis of Olfactory Function in Healthy People and Patients with Parkinson's Disease or Essential Tremor. Doctor.Ru. 2019; 6(161): 12–17. DOI: 10.31550/1727-2378-2019-161-6-12-17
10 June 07:43

Objective of the Study: To compare and analyze the results of an evaluation of olfactory function in healthy people and patients with Parkinson’s disease (PD) or essential tremor (ET).

Study Design: This was a comparative, cohort study.

Materials and Methods: The Sniffin’ Sticks olfactory test was used to evaluate patients with PD (n = 45), patients with ET (n = 40), and apparently healthy people (n = 64).

The data collected were processed using Student’s t-test, the Mann–Whitney test, the Kruskal-Wallis test, and a nonlinear method of elastic maps.

Study Results: The study found statistically significant (p ˂ 0.05) differences between 1) the PD group and 2) the ET and control groups. In particular, the proportions of subjects with anosmia and normal olfactory function were 31.1% and 2.2%, respectively, in the PD group, 5.0% and 17.5% in the ET group, and 4.7% and 45.3% in the control group. The proportion of people with hyposmia was substantial in all the groups, which may be associated with well-known age-related deficits in olfactory function.

Conclusion: The data obtained from the patients with PD were worse to a statistically significant degree than those obtained from the patients with ET and the healthy people. The first subtest of the Sniffin’ Sticks test was of minimal benefit, while the second and third subtests were of high diagnostic value and may be used in clinical practice. It is important to introduce the Sniffin’ Sticks test as a tool for early diagnosis of PD and differential diagnosis between PD and ET.


D.D. Pokhabov — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. Federal Siberian Clinical Research Center, Russian Federal Medical and Biological Agency; 26 Kolomenskaya St., Krasnoyarsk, Russian Federation 660037. E-mail: mr.lynch@mail.ru

M.E. Tunik — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. E-mail: tsuprikova.mary.maria@yandex.ru

V.G. Abramov — Federal Siberian Clinical Research Center, Russian Federal Medical and Biological Agency; 26 Kolomenskaya St., Krasnoyarsk, Russian Federation 660037. E-mail: excalibr@mail.ru

S.V. Prokopenko — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. Federal Siberian Clinical Research Center, Russian Federal Medical and Biological Agency; 26 Kolomenskaya St., Krasnoyarsk, Russian Federation 660037. eLIBRARY.RU SPIN: 1279-7072. E-mail: s.v.proc.58@mail.ru

D.V. Pokhabov — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. Federal Siberian Clinical Research Center, Russian Federal Medical and Biological Agency; 26 Kolomenskaya St., Krasnoyarsk, Russian Federation 660037. eLIBRARY.RU SPIN: 3984-8157. E-mail: neurodmit@mail.ru

M.G. Sadovsky — Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health; 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation 660022. Institute of Computational Modeling, Siberian Branch of the Russian Academy of Sciences; 50 Akademgorodok, Krasnoyarsk, Russian Federation 660036. eLIBRARY.RU SPIN: 5862-9142. E-mail: msad@icm.krasn.ru


The authors thank K.O. Tutsenko and A.A. Khoroshavina, students at the Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Ministry of Health, for their assistance in calculations during the data processing.

The authors declare that they do not have any conflict of interests.


Доктор.ру
10 June 07:43
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