Biochemical Markers of Hypoxic Brain Damage in Full-Term Newborns

Bibliography link: Panchenko A.S., Panova M.S. Biochemical Markers of Hypoxic Brain Damage in Full-Term Newborns. Doctor.Ru. 2020; 19(3): 12–16. (in Russian) DOI: 0.31550/1727-2378-2020-19-3-12-16
19 May 08:51

Study Objective: to assess biochemical markers of brain damage in full-term newborns who suffered from antenatal hypoxia and/or asphyxia at birth.

Study Design: retrospective cohort clinical study.

Materials and Methods. The study enrolled 142 full-term newborns divided into two groups: group 1 (study group) (n = 90) — children who suffered from antenatal hypoxia and/or asphyxia at birth; group 2 (controls) (n = 52) — children with Apgar score 8 and higher at birth who did not suffer from antenatal hypoxia. Neonatal records (gestation course and delivery, early neonatal period) were analysed retrospectively; the concentration of interleukins (IL-1β, IL-4, IL-6, IL-8) and neuro-specific enolase (NSE) in umbilical blood plasma was evaluated.

Study Results. The analysis of interleukins and NSE concentration identified statistically significant difference between groups. Markers in hypoxia episodes were significant raise in NSE levels — 9.63 (6.71; 14.94) and pro- and anti-inflammatory cytokines: IL-1β — 8.5 (0.09; 36.39), IL-6 — 14.11 (6.71; 141.0), IL-8 — 50.4 (10.8; 182.7), IL-4 — 0.90 (0.00; 3.84).

Conclusion. Central nervous system damages should be diagnosed using lab methods with evaluation of markers indicative of pathological process. Children with past antenatal hypoxia/ asphyxia demonstrate increased IL-1β, IL-6, IL-8, IL-4 and NSE levels; some children from the study group did not have any neurological symptoms and corresponding diagnosis.

Contribution: Panchenko, A.S. — thematic publications reviewing; study design; review of critically important material; approval of the manuscript for publication; Panova, M.S. — patients selection and evaluation; thematic publications reviewing; study design; review of critically important material; collection of clinical materials; data processing, analysis and interpretation; approval of the manuscript for publication.

Conflict of interest: The authors declare that they do not have any conflict of interests.

A.S. Panchenko (Corresponding author) — Chita State Medical Academy of the Ministry of Health of the Russian Federation; 39A Gorky Str., Chita, Russian Federation 672000. eLIBRARY.RU SPIN: 9552-2350. E-mail:

M.S. Panova — Chita State Medical Academy of the Ministry of Health of the Russian Federation; 39A Gorky Str., Chita, Russian Federation 672000. eLIBRARY.RU SPIN: 3461-5321. E-mail:


Interleukin (IL) concentration in umbilical blood plasma in newborns from the study group and control group, IU (25; 75)


Received: 29.01.2020
Accepted: 18.02.2020

19 May 08:51
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