Acute Respiratory Disorders in Children: Efficacy of Mucolytic Agents

22 June 08:37

Study Objective: To assess the efficacy of Herbion Cowslip Syrup in treating children with acute respiratory disorders (ARD).

Study Design: This was an open-label, post-marketing study.

Materials and Methods: We followed 80 children, ranging in age from 5 to 17, with ARD accompanied with cough. The main group included 50 children who received Herbion Cowslip Syrup. The control group included 30 children who were receiving ambroxol. The treatment efficacy was assessed on days 5 and 10, using a rating scale of ARD clinical symptoms, including coughing, and computer-digitized airway phonography as a tool to test pulmonary function.

Study Results: Baseline computer-digitized airway phonography showed that, in 64.5% of patients in the main group and 50.0% of patients in the control group, the high-frequency component of the work of breathing was enhanced. This signaled moderate airway obstruction.

By treatment day 5, in most patients (74%) in the main group, the frequency of cough had decreased, and sputum evacuation had become easier. In the main and control groups, the severity of cough had reduced from 2.7 ± 0.4 to 1.6 ± 0.2 (р < 0.05) and from 2.8 ± 0.4 to 1.9 ± 0.3, respectively, by treatment day 5 and from 0.1 ± 0.1 (р < 0.05) and from 0.3 ± 0.2 (р < 0.05), respectively, by treatment day 10. In 95% of children with airway obstruction who received treatment with Herbion Cowslip Syrup, the parameters of computer-digitized airway phonography normalized by treatment day 5.

Conclusion: Herbion Cowslip Syrup is effective in treating children who have ARD accompanied by cough, and has similar effects to those of mucolytic agents.

N. A. Geppe — I. M. Sechenov First Moscow State Medical University. E-mail:

M. V. Glukhova — I. M. Sechenov First Moscow State Medical University. E-mail:

A. R. Denisova — I. M. Sechenov First Moscow State Medical University. E-mail:

N. G. Kolosova — I. M. Sechenov First Moscow State Medical University. E-mail:

S. I. Shatalina — I. M. Sechenov First Moscow State Medical University. E-mail:

M. D. Shakhnazarova — I. M. Sechenov First Moscow State Medical University. E-mail:

22 June 08:37
  1. Геппе Н. А., Малахов А. Б. Муколитические и бронхолитические средства в терапии бронхиальной обструкции при ОРВИ у детей // Эффектив. фармакотерапия. 2012. № 17. С. 38–45.
  2. Геппе Н. А., Селиверстова Н. А., Малышев В. С., Утюшева М. Г. и др. Бронхофонографическое исследование легких у больных бронхиальной астмой раннего возраста // Пульмонология. 2008. № 3. С. 38–41.
  3. Геппе Н. А., Снегоцкая М. Н. Кашель у детей. Вопросы и ответы. Пособие для врачей. М.: изд-во ММА им. И. М. Сеченова, 2006. 18 с.
  4. Зайцева С. В., Локшина Э. Э., Зайцева О. В., Муратазаева О. А. и др. Рациональный выбор препаратов для лечения кашля у детей с острыми заболеваниями нижних дыхательных путей // Педиатрия. 2012. Т. 91. № 5. С. 79–85.
  5. Комплексный подход к лечению и профилактике острых респираторных инфекций у детей: Практическое руководство для врачей / Под ред. Н. А. Геппе, А. Б. Малахова. М., 2012. 47 с.
  6. Мизерницкий Ю. Л., Мельникова И. М. Муколитическая и отхаркивающая фармакотерапия при заболеваниях легких у детей. М.: Медпрактика-М, 2013. 120 с.
  7. Alving K., Malinovschi A. Basic aspects of exhaled nitric oxide // European Respiratory Society Monograph. 2010. Vol. 49. P. 1–31.
  8. Braga P. C., Dal Sasso M., Culici M., Galastri L. et al. Antioxidant potential of thymol determined by chemiluminescence inhibition in human neutrophils and cell-free systems // Pharmacology. 2006. Vol. 76. N 2. P. 61–68.
  9. Fabio A., Cermelli C., Fabio G., Nicoletti P. et al. Screening of the antibacterial effects of a variety of essential oils on microorganism responsible for respiratory infections // Phytoter. Res. 2007. Vol. 21. N 4. P. 374–377.
  10. Grunwald J., Graubaum H. J., Busch R., Bentley C. et al. Thyme and Primrose root: a powerful synergism for the therapy of acute bronchitis // Z. Phytother. 2006. N 27. P. 214–220.
  11. Nadel J. A. Mucous hypersecretion and relationship to cough // Pulm. Pharmacol. Ther. 2013. Vol. 26. N 5. P. 510–513.
  12. Nauert C., Bentley C., Fiebich B. L. In-vitro-Untersuchungen zur mukolytischen Wikkung liner fixen Kombinaqtion von Thymian und Primula // Z. Phytotherapie. 2005 (Kongressbamd.). S. 31.
  13. Primula radix (Primrose root) // ESCOP Monograph. 2nd ed. Elburg: European Scientific Cooperative on Phytomedicine, 2003.
  14. Shatalina S. I., Geppe N. A., Kolosova N. G., Malishev V. S. Computer bronchophonography (CBPG) — method of assessment of respiratory function in asthmatic children // Eur. Respir. J. 2013. Vol. 42. Suppl. 57. P. S922.
  15. Thymi herba (Thyme) // ESCOP Monograph. 2nd ed. Elburg: European Scientific Cooperative on Phytomedicine, 2003.
  16. Wienkotten N., Begrow F., Kinzinger U., Schierstedt D. et al. The effect of thyme extract on beta2-receptors and mucocilliary clearance // Planta Med. 2007. Vol. 73. N 7. P. 629–635.
Новости мировой медицины! Свежие статьи из журнала! Будьте в курсе!

Похожие статьи

Similar article
19 April 00:00, Interview
Doctor.Ru Pediatrics. Vol. 20, No. 3 (2021)
19 April 00:00, Paediatrics
A.V. Aksenov, E.A. Ivanovskaya
Successful Use of Tocilizumab in a Child with Systemic Juvenile Idiopathic Arthritis
Doctor.Ru Pediatrics. Vol. 20, No. 3 (2021)