ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Markers of Transient and Persistent Bronchial Obstruction Syndrome Phenotype in Children

DOI:10.31550/1727-2378-2019-160-5-11-14
Bibliography link: Savenkova N.D., Djumagaziev A.A., Bezrukova D.A., Raiskiy D.V. Markers of Transient and Persistent Bronchial Obstruction Syndrome Phenotype in Children. Doctor.Ru. 2019; 5(160): 11–14. DOI: 10.31550/1727-2378-2019-160-5-11-14
13 May 14:13

Study Objective: To identify the markers of transient and persistent bronchial obstruction syndrome (BOS) phenotypes in preschool and primary school-aged children.

Study Design: Prospective cohort clinical study.

Materials and Methods: 101 children with recurrent BOS aged 1 to 6 years old had their initial immunograms and serum interleukin (IL-1β, IL-4, IL-6, IL-8) concentrations assessed. During the further follow-up for 6 years 18 children were excluded from the study. The follow-up study allowed identifying the following comparisons from the remaining children: the group of children with transient BOS who did not have any disease relapses after 6 years of follow-up (group one, n = 39) and children with persistent BOS progressing into bronchial asthma (group two, n = 44). The control group comprised 32 conditionally healthy children of the respective age.

Study Results: The cytokine concentration analysis identified statistically significant differences between groups. IL-8 level in group 1 was 5.6 ± 0.6 pg/mL, whereas in group 2 it was 10.1 ± 1.6 pg/mL (р = 0.004); IL-4 level was 4.0 ± 0.4 pg/mL in group 1 and 9.9 ± 1.5 pg/mL in group 2 (р = 0.001).

Conclusion: These biomarkers allow identifying recurrent BOS phenotypes in children, making prognosis of disease and individualising therapy.

The authors declare that they do not have any conflict of interests.

N.D. Savenkova — Astrakhan State Medical University of the Ministry of Health of Russia; 121 Bakinskaya Str., Astrakhan, Russian Federation 414000. E-mail: savenkova.natasha@mail.ru

A.A. Djumagaziev — Astrakhan State Medical University of the Ministry of Health of Russia; 121 Bakinskaya Str., Astrakhan, Russian Federation 414000. E-mail: anver_d@mail.ru

D.A. Bezrukova — Astrakhan State Medical University of the Ministry of Health of Russia; 121 Bakinskaya Str., Astrakhan, Russian Federation 414000. E-mail: dina-bezrukova@mail.ru

D.V. Raiskiy — Astrakhan State Medical University of the Ministry of Health of Russia; 121 Bakinskaya Str., Astrakhan, Russian Federation 414000. E-mail: dm_eden@mail.ru

Доктор.ру
13 May 14:13
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