A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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First-Generation Antihistamines in Clinical Pediatric Practice

22 june 2015

Objective of the Review: To show the relevance of first-generation antihistamines and to describe their use in current clinical pediatric practice.

Key Points: The effects of first-generation antihistamines are explained by their high lipophilicity and their ability to block various receptors. These medications can block H1-receptors and counteract the effects of histamine. In addition to this, they have anticholinergic effects, central anticholinergic activity, local anesthetic properties and also block muscarinic and serotonin receptors. These medications are mainly used to treat acute allergic reactions, when the response is predominantly manifested as early-phase allergic-inflammation reactions.

Conclusion: First-generation antihistamines are still being used effectively. The choice of any antihistamine should take into account the drug's properties, the specific clinical features, and the patient's individual sensitivity.

N. A. Geppe — I. M. Sechenov First Moscow State Medical University. E-mail: geppe@mma.ru

I. V. Ozyorskaya — I. M. Sechenov First Moscow State Medical University. E-mail: doctor.ru@rusmg.ru

A. R. Denisova — I. M. Sechenov First Moscow State Medical University. E-mail: Anita_D@mail.ru

E. V. Frolkova — I. M. Sechenov First Moscow State Medical University. E-mail: fevdoc@mail.ru

Доктор.ру
22 June 06:59
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