Successful Use of Adalimumab in Children with Uveitis-Associated Juvenile Idiopathic Arthritis

For citation: Aksenov A.V., Ivanovskaya E.A. Successful Use of Adalimumab in Children with Uveitis-Associated Juvenile Idiopathic Arthritis. Doctor.Ru. 2021; 20(10): 73–75. (in Russian). DOI: 10.31550/1727-2378-2021-20-10-73-75
30 november 2021

Objective of the Paper: To describe clinical cases of successful use of adalimumab in children with uveitis-associated juvenile idiopathic arthritis (JIA).

Key Points. One of the extraarticular manifestations of JIA is uveitis, i. e. inflammation of the vascular tract of the eye. JIA-associated uveitis is diagnosed primarily in small girls with oligoarthritis, early seronegative polyarthritis; in patients with arthritis associated with enthesitis and psoriatic arthritis. The article describes clinical cases of the use of adalimumab in JIA and uveitis where the therapy with methotrexate and topical glucocorticosteroids fails.

Conclusion. Uveitis-associated JIA is one of the most disabling forms of JIA, since, despite timely and adequate management, very often it results in severe ocular complications: cataract, glaucoma and even blindness. Adalimumab, a human anti-TNFα monoclonal antibody, is available and it helps in achieving uveitis remission where methotrexate and topical glucocorticosteroids fail, as well as in delaying ocular complications.

Contributions: Aksenov, A.V. — thematic publications reviewing, text of the article, approval of the manuscript for publication; Ivanovskaya, E.A. — examination, material collection and therapeutic interventions.

Conflict of interest: The authors declare that they do not have any conflict of interests

A.V. Aksenov (Corresponding author) — South Ural State Medical University of the Ministry of Health of the Russian Federation; 64 Vorovskiy Str., Chelyabinsk, Russian Federation 454092. eLIBRARY.RU SPIN: 8688-8874. E-mail: alexandr.axyonov@yandex.ru

E.A. Ivanovskaya — Children’s City Clinical Hospital No.8; 2 Druzhby Str., Chelyabinsk, Russian Federation 454047. E-mail: Ivanovskaya.Elena@yandex.ru


Received: 21.05.2021

Accepted: 09.08.2021

30 November 00:00
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  6. Aksenov A.V., Ivanovskaya Е.А. Successful use of tocilizumab in a child with systemic juvenile idiopathic arthritis. Doctor.Ru. 2021; 20(3): 70–2 (in Russian). DOI: 10.31550/1727-2378-2021-20-3-70-72
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