Acute Renal Failure in Children with Hematological Malignancies

28 May 12:04

Objectives of the Review: 1) To discuss the basic principles of diagnosing acute renal damage and the specific features of this complication in children with hematological malignancies and 2) to define the indications for renal-replacement therapy (RRT).

Key Points: Acute renal failure is commonly seen in patients in intensive-care units and significantly complicates the underlying disease. The authors discuss their own experiences with renal-replacement therapies and compare that to published data. They also analyze the efficacy of these therapies in patients with a history of hematopoietic stem-cell transplantation. In addition, they focus on different treatment regimens used to prevent thrombotic events in patients receiving RRT and describe the use of regional citrate anticoagulation in patients at high risk of hemorrhage. The review also analyzes the possible complications of RRT and the mortality rate in patients with acute renal damage.

Conclusion: At the current stage of intensive-care development, RRT is becoming one of the main treatment options for severely-ill patients; others include mechanical ventilation. However, despite the fact that in children who have hematological malignancies renal function can be replaced at early stages, survival rates in subjects receiving this therapy remain very low, reflecting the severity of their overall status.

I. G. Khamin — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

M. N. Petrova — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

D. S. Lunev — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

V. V. Lazarev — N. I. Pirogov Russian National Research Medical University, Moscow. E-mail:

D. V. Litvinov — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

G. A. Novichkova — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

A. A. Mastchan — Dmitry Rogachyov Federal Scientific and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow. E-mail:

28 May 12:04
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