ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
Ru
En

Neurobiological and Personality Risk Factors for the Development of Obsessive-Compulsive Symptoms in Epilepsy Patients

For citation: Kalinin V. V., Zheleznova E. V., Zemlyanaya A. A., Sokolova L. V., Subbotin K. Yu. Neurobiological and Personality Risk Factors for the Development of Obsessive-Compulsive Symptoms in Epilepsy Patients. Doctor.Ru. 2017; 8(137): 32–37.
13 October 00:00

Study Objective: To search for possible interactions between personality constructs and obsessive-compulsive syndrome (OCS), in epilepsy patients with various combinations of seizure focus lateralization and motor lateralization.

Study Design: This was a comparative study.

Materials and Methods: One hundred and three patients with various types of epilepsy were examined. OCS was diagnosed in 19 patients.

The severity of obsessive and compulsive symptoms (a construct of obsessions) was assessed by Symptom CheckList 90 and premorbid personality traits were evaluated using the Munich Personality Test and Toronto Alexithymia Scale. The patients were divided into four groups by combinations of handedness and seizure focus lateralization. Multi-step regression analysis was conducted on the data collected from each group.

Study Results: In the premorbid phase, epilepsy patients with OCS presented with less extraversion and lower frustration tolerance, but more neuroticism, esoteric tendencies, and schizoid personality traits than patients without OCS. Alexithymia may be a risk factor for OCS only in left-handed patients, especially those with right-sided seizure focus. In right-handed patients with left-sided seizure focus, however, alexithymia may be protective against the development of OCS.

Conclusion: In epilepsy patients, premorbid personality traits are a prognostic factor for OCS only in cases of a certain combination of focus lateralization and handedness.

V. V. Kalinin — Moscow Research Institute of Psychiatry, a branch of the V. P. Serbsky National Medical Research Center for Psychiatry and Drug Abuse (a Federal Government-funded Institution), Russian Ministry of Health. E-mail: doct.kalinin@mail.ru

E. V. Zheleznova — Moscow Research Institute of Psychiatry, a branch of the V. P. Serbsky National Medical Research Center for Psychiatry and Drug Abuse (a Federal Government-funded Institution), Russian Ministry of Health. E-mail: e_zheleznova@mail.ru

A. A. Zemlyanaya — Moscow Research Institute of Psychiatry, a branch of the V. P. Serbsky National Medical Research Center for Psychiatry and Drug Abuse (a Federal Government-funded Institution), Russian Ministry of Health. E-mail: a_zemlyanaya@mail.ru

L. V. Sokolova — Moscow Research Institute of Psychiatry, a branch of the V. P. Serbsky National Medical Research Center for Psychiatry and Drug Abuse (a Federal Government-funded Institution), Russian Ministry of Health. E-mail: krilo_221160@mail.ru

K. Yu. Subbotin — Moscow Research Institute of Psychiatry, a branch of the V. P. Serbsky National Medical Research Center for Psychiatry and Drug Abuse (a Federal Government-funded Institution), Russian Ministry of Health. E-mail: katatonik@list.ru


Доктор.ру
13 October 00:00
LITERATURE
  1. Perini G.I., Tosin C., Carraro C., Bernasconi G., Canevini M.P., Canger R. et al. Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy. J. Neurol. Neurosurg. Psychiatry. 1996; 61(6): 601–5.
  2. Hermann B.P., Seidenberg M., Bell B. Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia. 2000; 41(Suppl. 2): S31–41.
  3. Mendez M.F., Cummings J.L., Benson D.F. Depression in epilepsy. Significance and phenomenology. Arch. Neurology. 1986; 43(8): 766–70.
  4. Mendez M.F., Taylor J.L., Doss R.C., Salguero P. Depression in secondary epilepsy: relation to lesion laterality. J. Neurol. Neurosurg. Psychiatry. 1994; 57(2): 232–3.
  5. Kanner A.M., Nieto J.C. Depressive disorders in epilepsy. Neurology. 1999; 53(Suppl. 2): S26–32.
  6. Kanner A. Depression in neurological disorders. Lundbeck Institute, Cambridge Medical Communication Ltd; 2005. 161 p.
  7. Monaco F., Cavanna A., Magli E., Barbagli D., Collimedaglia L., Cantello R. et al. Obsessionality, obsessive-compulsive disorder, and temporal lobe epilepsy. Epilepsy Behav. 2005; 7(3): 491–6.
  8. Bear D.M., Fedio P. Quantitative analysis of interictal behavior in temporal lobe epilepsy. Arch. Neurol. 1977; 34(8): 454–67.
  9. Rodin E., Schmaltz S. The Bear-Fedio personality inventory and temporal lobe epilepsy. Neurology. 1984; 34(5): 591–6.
  10. Gupta A.K., Ettinger A.B., Weisbrot D.M. Psychiatric comorbidity in epilepsy. In: Ettinger A.B., Devinsky O., eds. Managing epilepsy and co-existing disorders. Butterworth-Heinemann, Boston; 2002: 343–87.
  11. Tuke D.H. Imperative ideas. Brain. 1894; 17: 179–97.
  12. Berrios G.E. The history of mental symptoms. Descriptive psychopathology since the nineteenth century. Cambridge University Press; 2002. 565 p.
  13. Kalinin V.V., Zemlyanaya A.A., Krylov O.E., Zheleznova E.V. Handedness, alexithymia, and focus laterality as risk factors for psychiatric comorbidity in patients with epilepsy. Epilepsy Behav. 2010; 17(3): 389–94. DOI: 10.1016/j.yebeh.2009.12.028.
  14. Tellenbach H. Melancholie. Problemgeschichte, Endogenität, Typologie, Pathogenese, Klinik. 3 Auflage, Springer, Berlin; 1971.
  15. Zerssen D. von. Objektivirende Untersuchungen zur prämorbiden Persönlichkeit endogenen Depressiver (Methodik und vorläufig Ergebnisse). In: Hippius H., Selbach H., eds. Das depressive Syndrom. Urban und Schwarzenberg, München; 1969: 183–205.
  16. Zerssen D. von. Personality and affective disorders. In: Paykel E.S., ed. Handbook of Affective Disorders. Churchill Livingstone, Edinburgh; 1982: 212–28.
  17. Möller H-J. Zur Bedeutung und methodischen Problematik der psychiatrischen Persönlichkeitsforschung: der Typus melancholicus und andere Konzepte zur prämorbiden Persönlichkeit von Patienten mit affektiven Psychosen. In: Marneros A., Philipp M., eds. Persönlichkeit und Psychische Erkrankung. Springer-Verlag, Berlin; 1992: 45–65.
  18. Marneros A., Deister A., Rohde A. Prämorbide und postmorbide Persönlichkeitsmerkmale bei Patienten mit idiopathischen Psychosen. In: Marneros A., Philipp M., eds. Persönlichkeit und Psychische Erkrankung. Springer-Verlag, Berlin; 1992: 87–100.
  19. Furukawa T., Nakanishi M., Hamanaka T. Typus melancholicus is not the premorbid personality trait of unipolar (endogenous) depression. Psychiatry Clin. Neurosci. 1997; 51(4): 197–202.
  20. Zerssen D. von, Pfister H., Koeller D.M. The Munich Personality Test (MPT) — a short questionnaire for self-rating and relatives' rating of personality traits: formal properties and clinical potential. Eur. Arch. Psychiatry Neurol. Sci. 1988; 238(2): 73–93.
  21. Derogatis L.R., Lipman R.S., Covi L. SCL-90: an outpatient psychiatric rating scale — preliminary report. Psychopharmacol. Bull. 1973; 9(1): 13–28.
  22. Derogatis L.R., Cleary P.A. Confirmation of the dimensional structure of SCL-90: a study of construct validation. J. Clin. Psychol. 1977; 33: 981–9.
  23. Eysenck H.J., Eysenck S.B.G. Manual of the Eysenck Personality Inventory. London, Hodder & Stoughton; 1975.
  24. Kretschmer E. Körperbau und Charakter. 26 Auflage, Springer-Verlag, Berlin; 1977.
  25. Bagby R.M., Taylor G.J., Ryan D. Toronto Alexithymia Scale: relationship with personality and psychopathology measures. Psychother. Psychosom. 1986; 45(4): 207–15.
  26. Bagby R.M., Taylor G.J., Parker J.D., Loiselle C. Cross-validation of the factor structure of the Toronto Alexithymia Scale. J. Psychosom. Res. 1990; 34(1): 47–51.
  27. Annett M. A classification of hand preference by association analysis. Br. J. Psychol. 1970; 61(3): 303–21.
  28. Kalinin V.V., Zemlyanaya A.A., Zheleznova E.V., Krylov O.E. Premorbid Personality Traits, Focus Lateralization and Handedness as Risk Factors for Co-Morbid Affective and Anxiety Disorders in Temporal Lobe Epilepsy. Horizons in Neuroscience Research. Vol. 7/Eds. Andres Costa and Eugenio Villalba, Nova Publishers; 2012: 175–90.

News

30 June 00:00
A New Issue of Doctor.Ru Neurology Psychiatry, Vol. 20, No. 5 (2021), Published

Find original articles and reviews covering various aspects of neurology, psychiatry and the interview with Professor Marina Arkadievna Kinkulkina

28 June 00:00
A New Issue of Doctor.Ru Internal Medicine, Vol. 20, No. 4 (2021), Published

Find original articles and reviews covering various aspects of cardiology, gastroenterology, internal medicine and the interview with Professor Elena Zelikovna Golukhova

 

3 May 17:06
A New Issue of Doctor.Ru Pediatrics, Vol. 20, No. 3 (2021), Published

Find original articles and reviews covering various aspects of pediatrics and the interview with Professor Evgeny Grigorievich Furman

3 May 17:06
A New Issue of Doctor.Ru Endocrinology, Vol. 20, No. 2 (2021), Published

Find original articles and reviews covering various aspects of endocrinology and the interview with Professor Valentin Viktorovich Fadeev

16 April 11:57
Igor Evgenievich Khatkov joined the American Surgical Association

Igor Evgenievich Khatkov, Head of A. S. Loginov Moscow Clinical Scientific and Practical Centre, Chief Oncologist in and for Moscow is now an honoured member of the American Surgical Association.

All news