A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Challenges and Prospects for Research on Autonomic Regulation in Depression

DOI:10.31550/1727-2378-2019-161-6-42-46
For citation: Antipova O.S. Challenges and Prospects for Research on Autonomic Regulation in Depression. Doctor.Ru. 2019; 6(161): 42–46. DOI: 10.31550/1727-2378-2019-161-6-42-46
10 june 2019

Objective of the Review: To analyze the main methodological problems and identify areas for exploration in scientific research on autonomic regulation in depression.

Key Points: The most common and systematic studies in the current scientific literature on autonomic regulation in depression are those using analysis of heart rate variability. This paper discusses the results of these studies and the prospects they open up. The authors show that focusing solely on the operational diagnostic criteria used in current classifications may make it difficult to incorporate the results of such studies in clinical practice.

Conclusion: Studies of autonomic regulation will help in better understanding the pathogenesis and sanogenesis of various clinical types of depression, and in optimizing therapeutic and rehabilitation strategies.

O.S. Antipova — Psychiatry and Narcology, Russian Ministry of Health; 3 Poteshnaya St., Bldg. 10, Moscow, Russian Federation 107076. eLIBRARY.RU SPIN: 6133-1330. E-mail: olgaant77@gmail.com

The authors declare that they do not have any conflict of interests.

Доктор.ру
10 June 07:43
REFERENCES
  1. Краснов В.Н. Расстройства аффективного спектра. М.: Практическая медицина; 2011. 432 с. [Krasnov V.N. Rasstroistva affektivnogo spektra. M.: Prakticheskaya meditsina; 2011. 432 s. (in Russian)]
  2. Протопопов В.П. Избранные труды. Киев: изд-во АН УССР; 1961. 366 с. [Protopopov V.P. Izbrannye trudy. Kiev: izd-vo AN USSR; 1961. 366 s. (in Russian)]
  3. Вертоградова О.П. Возможные подходы к типологии депрессии. В кн.: Вертоградова О.П., ред. Депрессия (психопатология, патогенез): Труды Московского НИИ психиатрии. М.: изд-во МНИИП МЗ РСФСР; 1980: 9–16. [Vertogradova O.P. Vozmozhnye podkhody k tipologii depressii. V kn.: Vertogradova O.P., red. Depressiya (psikhopatologiya, patogenez): Trudy Moskovskogo NII psikhiatrii. M.: izd-vo MNIIP MZ RSFSR; 1980: 9–16. (in Russian)]
  4. Краснов В.Н. Закономерности динамики депрессий: клинические, патогенетические и терапевтические аспекты. В кн.: Смулевич А.Б., ред. Депрессия и коморбидные расстройства. М.: изд-во НЦПЗ РАМН; 1997: 80–97. [Krasnov V.N. Zakonomernosti dinamiki depressii: klinicheskie, patogeneticheskie i terapevticheskie aspekty. V kn.: Smulevich A.B., red. Depressiya i komorbidnye rasstroistva. M.: izd-vo NTsPZ RAMN; 1997: 80–97. (in Russian)]
  5. Диков С.Ю. Соматовегетативные расстройства при депрессиях с разным типом ведущего аффекта: Дисс. ... канд. мед. наук. М., 2009. 164 с. [Dikov S.Yu. Somatovegetativnye rasstroistva pri depressiyakh s raznym tipom vedushchego affekta: Diss. ... kand. med. nauk. M., 2009. 164 s. (in Russian)]
  6. Антипова О.С., Краснов В.Н., Трофимова О.С. Изменения вегетативной регуляции при депрессивных расстройствах умеренной тяжести. Журн. неврологии и психиатрии им. С.С. Корсакова. 2013; 11(2): 65–73. [Antipova O.S., Krasnov V.N., Trofimova O.S. Izmeneniya vegetativnoi regulyatsii pri depressivnykh rasstroistvakh umerennoi tyazhesti. Zhurn. nevrologii i psikhiatrii im. S.S. Korsakova. 2013; 11(2): 65–73. (in Russian)]
  7. Антипова О.С., Трофимова О.С. Вегетативная реактивность больных депрессией на фоне купирующей терапии антидепрессантами группы селективных ингибиторов обратного захвата серотонина. Учен. записки Санкт-Петербургского гос. мед. ун-та им. акад. И.П. Павлова. 2009; XVI(4): 32–4. [Antipova O.S., Trofimova O.S. Vegetativnaya reaktivnost' bol'nykh depressiei na fone kupiruyushchei terapii antidepressantami gruppy selektivnykh ingibitorov obratnogo zakhvata serotonina. Uchen. zapiski Sankt-Peterburgskogo gos. med. un-ta im. akad. I.P. Pavlova. 2009; XVI(4): 32–4. (in Russian)]
  8. Андрушкявичус С.И. Циркадианные изменения вариабельности сердечного ритма при циркулярных депрессиях. Доктор.Ру. 2011; 63(4): 42–7. [Andrushkyavichus S.I. Tsirkadiannye izmeneniya variabel'nosti serdechnogo ritma pri tsirkulyarnykh depressiyakh. Doktor.Ru. 2011; 63(4): 42–7. (in Russian)]
  9. Хауликэ И. Вегетативная нервная система. Бухарест: Медицинское издание; 1978. 350 с. [Khaulike I. Vegetativnaya nervnaya sistema. Bukharest: Meditsinskoe izdanie; 1978. 350 s. (in Russian)]
  10. Вейн А.М., ред. Вегетативные расстройства. Клиника. Диагностика. Лечение. М.: МИА; 2000. 434 с. [Vein A.M., red. Vegetativnye rasstroistva. Klinika. Diagnostika. Lechenie. M.: MIA; 2000. 434 s. (in Russian)]
  11. Friedman B.H. An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biol. Psychol. 2007; 74(23):185–99. DOI: 10.1016/j.biopsycho.2005.08.009
  12. Thayer J.F., Lane R.D. A model of neurovisceral integration in emotion regulation and dysregulation. J. Affect. Disord. 2000; 61(3): 201–16.
  13. Porges S.W. The polyvagal theory: neurophysiological foundations of emotions, attachment, communication, and self-regulation. 1st ed. New York: W.W. Norton & Company; 2011. 347 p.
  14. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996; 93(5): 1043–65.
  15. Баевский Р.М., Иванов Г.Г., Чирейкин Л.В. и др., сост. Анализ вариабельности сердечного ритма при использовании различных электрокардиографических систем: Метод. рекомендации. Ижевск: изд-во Удмуртского ун-та; 2003: 201–55. [Baevskii R.M., Ivanov G.G., Chireikin L.V. i dr., sost. Analiz variabel'nosti serdechnogo ritma pri ispol'zovanii razlichnykh elektrokardiograficheskikh sistem: Metod. rekomendatsii. Izhevsk: izd-vo Udmurtskogo un-ta; 2003: 201–55. (in Russian)]
  16. Михайлов В.М. Вариабельность ритма сердца: опыт практического применения метода. Изд. 2-е, перераб. и доп. Иваново: изд-во Ивановской. гос. мед. акад.; 2002. 290 с. [Mikhailov V.M. Variabel'nost' ritma serdtsa: opyt prakticheskogo primeneniya metoda. Izd. 2-e, pererab. i dop. Ivanovo: izd-vo Ivanovskoi. gos. med. akad.; 2002. 290 s. (in Russian)]
  17. Хаспекова Н.Б. Регуляция вариативности ритма сердца у здоровых и больных с психогенной и органической патологией мозга: Дисс. … докт. мед. наук. Москва, ИВНД и НФ РАН. М.; 1996. 217 с. [Khaspekova N.B. Regulyatsiya variativnosti ritma serdtsa u zdorovykh i bol'nykh s psikhogennoi i organicheskoi patologiei mozga: Diss. … dokt. med. nauk. Moskva, IVND i NF RAN. M.; 1996. 217 s. (in Russian)]
  18. Баевский Р.М., Кирилов О.И., Клецкин С.З. Математический анализ изменений сердечного ритма при стрессе. М.: Наука; 1984. 221 с. [Baevskii R.M., Kirilov O.I., Kletskin S.Z. Matematicheskii analiz izmenenii serdechnogo ritma pri stresse. M.: Nauka; 1984. 221 s. (in Russian)]
  19. Мельникова Т.С., Хананашвили М.М., Дикая В.И., Пантелеева Г.П. Особенности вегетативной регуляции у больных сезонными депрессиями. Журн. невропатологии и психиатрии им. С.С. Корсакова. 2000; 100(8): 16–9. [Mel'nikova T.S., Khananashvili M.M., Dikaya V.I., Panteleeva G.P. Osobennosti vegetativnoi regulyatsii u bol'nykh sezonnymi depressiyami. Zhurn. nevropatologii i psikhiatrii im. S.S. Korsakova. 2000; 100(8): 16–9. (in Russian)]
  20. Borrione L., Brunoni A.R., Sampaio-Junior B., Aparicio L.M., Kemp A.H., Benseñor I. et al. Associations between symptoms of depression and heart rate variability: An exploratory study. Psychiatry Res. 2018; 262: 482–7. DOI: 10.1016/j.psychres.2017.09.028
  21. Beauchaine T.P., Thayer J.F. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int. J. Psychophysiol. 2015; 98(2 Pt. 2): 338–50. DOI: 10.1016/j.ijpsycho.2015.08.004
  22. Brown L., Karmakar C., Gray R., Jindal R., Lim T., Bryant C. Heart rate variability alterations in late life depression: A meta-analysis. J. Affect. Disord. 2018; 235: 456–66. DOI: 10.1016/j.jad.2018.04.071
  23. Hamilton J.L., Alloy L.B. Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research. Clin. Psychol. Rev. 2016; 50: 67–79. DOI: 10.1016/j.cpr.2016.09.003
  24. Kemp A.H., Quintana D.S. The relationship between mental and physical health: insights from the study of heart rate variability. Int. J. Psychophysiol. 2013; 89(3): 288–96. DOI: 10.1016/j.ijpsycho.2013.06.018
  25. Kemp A.H., Koenig J., Thayer J.F. From psychological moments to mortality: A multidisciplinary synthesis on heart rate variability spanning the continuum of time. Neurosci. Biobehav. Rev. 2017; 83: 547–67. DOI: 10.1016/j.neubiorev.2017.09.006
  26. Jandackova V.K., Britton A., Malik M., Steptoe A. Heart rate variability and depressive symptoms: a cross-lagged analysis over a 10-year period in the Whitehall II study. Psychol. Med. 2016; 46(10): 2121–31. DOI: 10.1017/S003329171600060X
  27. Ottaviani C., Thayer J.F., Verkuil B., Lonigro A., Medea B., Couyoumdjian A. et al. Physiological concomitants of perseverative cognition: A systematic review and meta-analysis. Psychol. Bull. 2016; 142(3): 231–59. DOI: 10.1037/bul0000036
  28. Мельникова Т.С., Капилетти С.Г., Мариненко К.Е., Цукарзи Э.Э., Мосолов С.Н. Динамика вегетативной регуляции при лечении транскраниальной магнитной стимуляцией больных эндогенными депрессиями. Журн. соц. и клин. психиатрии. 2001; 2: 72–5. [Mel'nikova T.S., Kapiletti S.G., Marinenko K.E., Tsukarzi E.E., Mosolov S.N. Dinamika vegetativnoi regulyatsii pri lechenii transkranial'noi magnitnoi stimulyatsiei bol'nykh endogennymi depressiyami. Zhurn. sots. i klin. psikhiatrii. 2001; 2: 72–5. (in Russian)]
  29. Holzman J.B., Bridgett D.J. Heart rate variability indices as bio-markers of top-down self-regulatory mechanisms: A meta-analytic review. Neurosci. Biobehav. Rev. 2017; 74(Pt. A): 233–55. DOI: 10.1016/j.neubiorev.2016.12.032
  30. Thayer J.F., Ahs F., Fredrikson M., Sollers J.J. 3rd, Wager T.D. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci. Biobehav. Rev. 2012; 36(2): 747–56. DOI: 10.1016/j.neubiorev.2011.11.009
  31. Hage B., Britton B., Daniels D., Heilman K., Porges S.W., Halaris A. Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression. World J. Biol. Psychiatry. 2019; 20(5): 359–67. DOI: 10.1080/15622975.2017.1376113
  32. Davydov D.M., Shapiro D., Cook I.A., Goldstein I. Baroreflex mechanisms in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2007; 31(1): 164–77. DOI: 10.1016/j.pnpbp.2006.08.015
  33. Pinter A., Szatmari S. Jr., Horvath T., Penzlin A.I., Barlinn K., Siepmann M. et al. Cardiac dysautonomia in depression — heart rate variability biofeedback as a potential add-on therapy. Neuropsychiatr. Dis. Treat. 2019; 15: 1287–310. DOI: 10.2147/NDT.S200360
  34. Carney R.M., Freedland K.E. Depression and coronary heart disease. Nat. Rev. Cardiol. 2017; 14(3): 145–55. DOI: 10.1038/nrcardio.2016.181
  35. Glassman A.H., O'Connor C.M., Califf R.M., Swedberg K., Schwartz P., Bigger J.T. Jr. et al.; Sertraline Antidepressant Heart Attack Randomized Trial (SADHEART) Group. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002; 288(6): 701–9. DOI: 10.1001/jama.288.6.701
  36. O'Regan C., Kenny R.A., Cronin H., Finucane C., Kearney P.M. Antidepressants strongly influence the relationship between depression and heart rate variability: findings from The Irish Longitudinal Study on Ageing (TILDA). Psychol. Med. 2015; 45(3): 623–36. DOI: 10.1017/S0033291714001767
  37. Pittig A., Arch J.J., Lam C.W., Craske M.G. Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation. Int. J. Psychophysiol. 2013; 87(1): 19–27. DOI: 10.1016/j.ijpsycho.2012.10.012
  38. Faurholt-Jepsen M., Kessing L.V., Munkholm K. Heart rate variability in bipolar disorder: A systematic review and meta-analysis. Neurosci. Biobehav. Rev. 2017; 73: 68–80. DOI: 10.1016/j.neubiorev.2016.12.007
  39. Quintana D.S., Westlye L.T., Kaufmann T., Rustan Ø.G., Brandt C.L., Haatveit B. et al. Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls. Acta Psychiatr. Scand. 2016; 133(1): 44–52. DOI: 10.1111/acps.12498
  40. Moon E., Lee S.H., Kim D.H., Hwang B. Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder. Clin. Psychopharmacol. Neurosci. 2013; 11(3): 137–43. DOI: 10.9758/cpn.2013.11.3.137
  41. Резников М.К. Системный подход к оценке вегетативных нарушений у больных параноидной шизофренией. Системный анализ и управление в биомед. системах. 2007; 7(3): 665–7. [Reznikov M.K. Sistemnyi podkhod k otsenke vegetativnykh narushenii u bol'nykh paranoidnoi shizofreniei. Sistemnyi analiz i upravlenie v biomed. sistemakh. 2007; 7(3): 665–7. (in Russian)]
  42. Bär K.J. Cardiac Autonomic Dysfunction in Patients with Schizophrenia and Their Healthy Relatives — A Small Review. Front. Neurol. 2015; 6: 139. DOI: 10.3389/fneur.2015.00139
  43. Schulz S., Bolz M., Bär K.J., Voss A. Central- and autonomic nervous system coupling in schizophrenia. Philos. Trans. A Math. Phys. Eng. Sci. 2016; 374(2067). PII: 20150178. DOI: 10.1098/rsta.2015.0178
  44. van Zyl L.T., Hasegawa T., Nagata K. Effects of antidepressant treatment on heart rate variability in major depression: a quantitative review. Biopsychosoc. Med. 2008; 2: 12. DOI: 10.1186/1751-0759-2-12
  45. Licht C.M., de Geus E.J., van Dyck R., Penninx B.W. Longitudinal evidence for unfavorable effects of antidepressants on heart rate variability. Biol. Psychiatry. 2010; 68(9): 861–8. DOI: 10.1016/j.biopsych.2010.06.032
  46. Terhardt J., Lederbogen F., Feuerhack A., Hamann-Weber B., Gilles M., Schilling C. et al. Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine. Clin. Neuropharmacol. 2013; 36(6): 198–202. DOI: 10.1097/WNF.0b013e3182a76fbb
  47. Kemp A.H., Fráguas R., Brunoni A.R., Bittencourt M.S., Nunes M.A., Dantas E.M. et al. Differential Associations of Specific Selective Serotonin Reuptake Inhibitors With Resting-State Heart Rate and Heart Rate Variability: Implications for Health and Well-Being. Psychosom. Med. 2016; 78(7): 810–8. DOI: 10.1097/PSY.0000000000000336
  48. Agelink M.W., Boz C., Ullrich H., Andrich J. Relationship between major depression and heart rate variability. Clinical consequences and implications for antidepressive treatment. Psychiatry Res. 2002; 113(1–2): 139–49.
  49. Licht C.M., de Geus E.J., Zitman F.G., Hoogendijk W.J., van Dyck R., Penninx B.W. Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch. Gen. Psychiatry. 2008; 65(12): 1358–67. DOI: 10.1001/archpsyc.65.12.1358

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