ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Amiodarone-Induced Alveolitis: Analysis of Publications and Authors’ Observations

5 March 08:24

Objective of the Paper: To improve the diagnosis of and to optimize the treatment strategies for amiodarone-induced alveolitis (amiodarone lung).

Key Points: The article includes an analysis of literature data and an evaluation of 17 authors' own observations. Patients underwent a complex examination that included chest computed tomography, comprehensive pulmonary-function tests, and a Doppler echocardiography. The article also describes a clinical case, which illustrates the difficulties in diagnosing and treating amiodarone lung.

Conclusion: When amiodarone lung is suspected, the differential diagnosis should include cardiovascular diseases, neoplastic diseases and interstitial lung disease.

G. P. Orlova — I. P. Pavlov First St. Petersburg State Medical University. E-mail: galorlova@mail.ru

M. M. Il’kovich — I. P. Pavlov First St. Petersburg State Medical University. E-mail: mih.ilkovich@yandex.ru

Yu. V. Nikolaeva — I. P. Pavlov First St. Petersburg State Medical University. E-mail: jut@yandex.ru

A. A. Speranskaya — I. P. Pavlov First St. Petersburg State Medical University. E-mail: a.spera@mail.ru

Доктор.ру
5 March 08:24
LITERATURE
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  2. Byrd R. P. Jr., Roy T. M. Drug-Induced Pulmonary Toxicity. URL: http://emedicine.medscape.com/article/1343451-overview (дата обращения — 08.05.2015).
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  4. Card J. W., Racz W. J., Brien J. F., Massey T. E. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction // J. Pharmacol. Exp. Ther. 2003. Vol. 304. N 1. P. 277–283.
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  13. Tanawuttiwat Т., Harindhanavudhi T., Hanif S., Sahloul M. Z. Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication // Heart Lung Circ. 2010. Vol. 19. N 7. P. 435–437.
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